SYNTHESIS AND SMOOTHMUSCLE CALCIUM CHANNEL ANTAGONIST EFFECT OF ALKYL, MINOALKYL 1,4- DIHYDRO-2,6-DIMETHYL-4-NITROIMIDAZOLE-3,5 PYRIDINE DICARBOXYLATES

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MIRI R.; DEHPOUR A.R.; AZIMI M.; SHAFIEI A.

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2001 | Volume:9 | Issue:3-4 Page(s): 40-45

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Information Journal Paper

Title

SYNTHESIS AND SMOOTHMUSCLE CALCIUM CHANNEL ANTAGONIST EFFECT OF ALKYL, MINOALKYL 1,4- DIHYDRO-2,6-DIMETHYL-4-NITROIMIDAZOLE-3,5 PYRIDINE DICARBOXYLATES

Author(s)

MIRI R. | DEHPOUR A.R. | AZIMI M. | SHAFIEI A. | Issue Writer Certificate

Keywords

CA+2 CHANNEL ANTAGONIST

NITROIMIDAZOLE

DHP

ARYLPIPERAZINE

Abstract

The discovery that 1,4-dihydropyridine (DHP) class of calcium channel antagonist inhibits the Ca+2 influx represented a major therapeutic advance in the treatment of cardiovascular diseases such as hypertension, angina pectoris and other spastic smooth muscle disorders. A novel class of calcium channel antagonist of flunarizine containing arylpiperazinyl moiety has recently been reported. It was therefore of interest to determine the effect that selected C-3 substituents contained amino alkyl and ARYLPIPERAZINE, in conjunction with a C-4 1-methyl-5-nitro-2-imidazolyl substituents on calcium channel antagonist activity. The unsymmetrical analogues were prepared by a procedure reported by Meyer in which 1-methyl-5-nitro-imidazol-2-carboxaldehyde was reacted with acetoacetic esters and alkyl 3-aminocrotonate. In vitro calcium channel antagonist activities were determined by the use of high K+ contraction of guinea pig ileal longitudinal smooth muscle. All compounds exhibited comparable calcium channel antagonist activity (IC-950=10 to 10 -11M) against reference drug nifedipine (IC50= 2.75±0.36x 10-10 M).

Cites

@SYNTHESIS AND SMOOTH MUSCLE CALCIUM CHANNEL ANTAGONIST EFFECT OF ALKYL, AMINOALKYL 1,4-DIHYDRO-2,6-DIMETHYL-4-NITROIMIDAZOLE-3,5 PYRIDINE DICARBOXYLATES

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APA: Copy

MIRI, R., DEHPOUR, A.R., AZIMI, M., & SHAFIEI, A.. (2001). SYNTHESIS AND SMOOTHMUSCLE CALCIUM CHANNEL ANTAGONIST EFFECT OF ALKYL, MINOALKYL 1,4- DIHYDRO-2,6-DIMETHYL-4-NITROIMIDAZOLE-3,5 PYRIDINE DICARBOXYLATES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 9(3-4), 40-45. SID. https://sid.ir/paper/275289/en

Vancouver: Copy

MIRI R., DEHPOUR A.R., AZIMI M., SHAFIEI A.. SYNTHESIS AND SMOOTHMUSCLE CALCIUM CHANNEL ANTAGONIST EFFECT OF ALKYL, MINOALKYL 1,4- DIHYDRO-2,6-DIMETHYL-4-NITROIMIDAZOLE-3,5 PYRIDINE DICARBOXYLATES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2001;9(3-4):40-45. Available from: https://sid.ir/paper/275289/en

IEEE: Copy

R. MIRI, A.R. DEHPOUR, M. AZIMI, and A. SHAFIEI, “SYNTHESIS AND SMOOTHMUSCLE CALCIUM CHANNEL ANTAGONIST EFFECT OF ALKYL, MINOALKYL 1,4- DIHYDRO-2,6-DIMETHYL-4-NITROIMIDAZOLE-3,5 PYRIDINE DICARBOXYLATES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 9, no. 3-4, pp. 40–45, 2001, [Online]. Available: https://sid.ir/paper/275289/en

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