INTERACTION OF L-ARGININE/NITRIC OXIDE SYSTEM WITH LEAD ACETATE ON SECRETION OF AMYLASE FROM ISOLATED RAT PAROTID GLANDS

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ABDOLLAHI M.; ZADEHKABIR R.; RAHMAT JIRDEH N.; DEHPOUR A.R.

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2001 | Volume:9 | Issue:3-4 Page(s): 50-57

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Title

INTERACTION OF L-ARGININE/NITRIC OXIDE SYSTEM WITH LEAD ACETATE ON SECRETION OF AMYLASE FROM ISOLATED RAT PAROTID GLANDS

Author(s)

ABDOLLAHI M. | ZADEHKABIR R. | RAHMAT JIRDEH N. | DEHPOUR A.R. | Issue Writer Certificate

Keywords

LEAD

PAROTID

AMYLASE

NITRIC OXIDE

L-NAME

Abstract

In the present study the effects of LEAD acetate and/or L-Arginine as a NITRIC OXIDE precursor and L-NAME as a NITRIC OXIDE synthase inhibitor on the AMYLASE secretion of rat PAROTID gland lobules were investigated. LEAD acetate in doses of 3, 30 and 300 mM significantly (P<0.01) caused a dose-dependent reduction in isoproterenol-stimulated or non-stimulated AMYLASE secretion. When secretion of saliva was not stimulated by beta-adrenergic agonist, L-Arginine (100 mM) significantly (P<0.01) reduced AMYLASE output. L-NAME (100 mM) alone had no significant effect on AMYLASE output but when used with LEAD acetate prevented (P<0.01) from LEAD-induced reduction of AMYLASE output. Both L-NAME (100 mM) and L-Arginine (100 mM)) when used alone reduced isoproterenol-stimulated AMYLASE output. Concurrent administration of LEAD acetate (300 mM)) with either L-Arginine (100 mM) or L-NAME (100 mM) showed a marked positive interaction in reducing the isoproterenol-stimulated secretion of AMYLASE. These findings suggest that NITRIC OXIDE plays a role in secretion of AMYLASE from PAROTID. Different affinity of LEAD acetate to interact with different NITRIC OXIDE synthases might be a reason for different effects on PAROTID AMYLASE secretion observed in the presence or absence of secretion stimulant.

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APA: Copy

ABDOLLAHI, M., ZADEHKABIR, R., RAHMAT JIRDEH, N., & DEHPOUR, A.R.. (2001). INTERACTION OF L-ARGININE/NITRIC OXIDE SYSTEM WITH LEAD ACETATE ON SECRETION OF AMYLASE FROM ISOLATED RAT PAROTID GLANDS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 9(3-4), 50-57. SID. https://sid.ir/paper/275290/en

Vancouver: Copy

ABDOLLAHI M., ZADEHKABIR R., RAHMAT JIRDEH N., DEHPOUR A.R.. INTERACTION OF L-ARGININE/NITRIC OXIDE SYSTEM WITH LEAD ACETATE ON SECRETION OF AMYLASE FROM ISOLATED RAT PAROTID GLANDS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2001;9(3-4):50-57. Available from: https://sid.ir/paper/275290/en

IEEE: Copy

M. ABDOLLAHI, R. ZADEHKABIR, N. RAHMAT JIRDEH, and A.R. DEHPOUR, “INTERACTION OF L-ARGININE/NITRIC OXIDE SYSTEM WITH LEAD ACETATE ON SECRETION OF AMYLASE FROM ISOLATED RAT PAROTID GLANDS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 9, no. 3-4, pp. 50–57, 2001, [Online]. Available: https://sid.ir/paper/275290/en

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