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Information Journal Paper

Title

ALTERATION OF PENTYLENETETRAZOL-INDUCED KINDLING PARAMETERS BY PRENATAL CHRONIC LEAD EXPOSURE IN RATS

Pages

  24-27

Keywords

PTZ 
RAT 

Abstract

 The effect of PRENATAL chronic LEAD exposure on pentylenetetrazol (PTZ)-induced KINDLING parameters (seizure index, seizure latency and seizure stage) in RATs was studied. Adult female RATs with a weight range of 140-180 g were selected and pretreated with LEAD acetate (0.05% w/v) orally, 25 days prior to mating. The control group was given distilled water containing sodium acetate solution (0.05% w/v). After delivery, treatment was ceased, and after lactation, male neonates were separated from the females in both groups. After maturation of male RATs, the PTZ-kindling was induced by daily interapritoneally injection of PTZ (30 mg/kg). KINDLING parameters in the control and treated groups were determined. The results indicated that animals with PRENATAL LEAD exposure have full KINDLING state with 9-19 (16.87±1.54) injections, whereas this value for control group was 12-23 (18.62±1.48) injections. The seizure latency for the treated group was lower (P<0.05) than the control (2.29±0.44 min versus 3.65±0.45 min). The seizure severity (regarding to seizure index) was statistically higher in the treated group (P<0.05). The seizure stages were also different in the treated and control groups (P<0.05). The seizure frequency of first and second stages of KINDLING in the control group was higher than that of treated one (P<0.05). Also the seizure frequency in the third and fourth KINDLING stages of case group was higher than controls (P<0.05). It is concluded that PRENATAL LEAD exposure alters seizure susceptibility in RAT PTZ-Kindling model.

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    • Cite

    APA: Copy

    KEBRIAEIZADEH, A., MASIHAYE AKBAR, R., & SOLTANINEZHAD, K.. (2001). ALTERATION OF PENTYLENETETRAZOL-INDUCED KINDLING PARAMETERS BY PRENATAL CHRONIC LEAD EXPOSURE IN RATS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 9(3-4), 24-27. SID. https://sid.ir/paper/275292/en

    Vancouver: Copy

    KEBRIAEIZADEH A., MASIHAYE AKBAR R., SOLTANINEZHAD K.. ALTERATION OF PENTYLENETETRAZOL-INDUCED KINDLING PARAMETERS BY PRENATAL CHRONIC LEAD EXPOSURE IN RATS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2001;9(3-4):24-27. Available from: https://sid.ir/paper/275292/en

    IEEE: Copy

    A. KEBRIAEIZADEH, R. MASIHAYE AKBAR, and K. SOLTANINEZHAD, “ALTERATION OF PENTYLENETETRAZOL-INDUCED KINDLING PARAMETERS BY PRENATAL CHRONIC LEAD EXPOSURE IN RATS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 9, no. 3-4, pp. 24–27, 2001, [Online]. Available: https://sid.ir/paper/275292/en

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