EVALUATION OF CARDIOVASCULAR EFFECT OF PYCNOCYCLA SPINOSA DECNE. EXBOISS. VAR. SPINOSA EXTRACT IN ANAESTHETIZED RAT

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ASGHARI GH.; HAJ HASHEMI V.A.; NEZAMI M.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2006 | Volume:14 | Issue:1 Page(s): 11-14

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Title

EVALUATION OF CARDIOVASCULAR EFFECT OF PYCNOCYCLA SPINOSA DECNE. EXBOISS. VAR. SPINOSA EXTRACT IN ANAESTHETIZED RAT

Author(s)

ASGHARI GH. | HAJ HASHEMI V.A. | NEZAMI M. | Issue Writer Certificate

Keywords

PYCNOCYCLA SPINOSA VAR. SPINOSA

HYDROALCOHOLIC EXTRACT

BLOOD PRESSURE

HEART RATE

ANTIDIARRHOEAL.

Abstract

Hydroalcoholic extract of Pycnocycla spinosa Decne. exBoiss. var. spinosa has in vitro spasmolytic action, and at oral dose of 250µg/kg inhibits castor oil induced diarrhoea in mice. In this investigation, effects of P. spinosa var. spinosa extract in comparison with nifedipine on BLOOD PRESSURE and HEART RATE in animal model was studied. Injection of three bolus doses of P. spinosa var. spinosa extract (100µg/kg, 500µg/kg and 1mg/kg) into the jugular vein, temporary reduced BLOOD PRESSURE and heart rate. However, soon after completion of extract administration BLOOD PRESSURE and HEART RATE returned to normal. Nifedipine on the other hand caused a sustained reduction in BLOOD PRESSURE and decreased HEART RATE compared with the control group. From this study it was concluded that P. spinosa var. spinosa extract at ANTIDIARRHOEAL.dose has no significant effect on BLOOD PRESSURE and heart rate.

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APA: Copy

ASGHARI, GH., HAJ HASHEMI, V.A., & NEZAMI, M.. (2006). EVALUATION OF CARDIOVASCULAR EFFECT OF PYCNOCYCLA SPINOSA DECNE. EXBOISS. VAR. SPINOSA EXTRACT IN ANAESTHETIZED RAT. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 14(1), 11-14. SID. https://sid.ir/paper/275332/en

Vancouver: Copy

ASGHARI GH., HAJ HASHEMI V.A., NEZAMI M.. EVALUATION OF CARDIOVASCULAR EFFECT OF PYCNOCYCLA SPINOSA DECNE. EXBOISS. VAR. SPINOSA EXTRACT IN ANAESTHETIZED RAT. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2006;14(1):11-14. Available from: https://sid.ir/paper/275332/en

IEEE: Copy

GH. ASGHARI, V.A. HAJ HASHEMI, and M. NEZAMI, “EVALUATION OF CARDIOVASCULAR EFFECT OF PYCNOCYCLA SPINOSA DECNE. EXBOISS. VAR. SPINOSA EXTRACT IN ANAESTHETIZED RAT,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 14, no. 1, pp. 11–14, 2006, [Online]. Available: https://sid.ir/paper/275332/en

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