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Information Journal Paper

Title

INTERACTION BETWEEN KETOCONAZOLE, AMPHOTERICIN B AND TERBINAFIN AND THREE DIAZENUMDIOLATES IN CONCOMITANT USES AGAINST SOME FUGAL SPECIES

Pages

  87-92

Abstract

 A checkerboard broth microdilution method was performed to investigate the in vitro ANTIFUNGAL ACTIVITIES of three DIAZENIUMDIOLATES derivatives (DETA/NO, DPTA/NO, DEA/NO) alone and in combination with KETOCONAZOLE, amphotricin B or TERBINAFINE against five Candida species, Cryptococcus neoformance and four dermatophyte strains. MICs and MLCs were recorded, and synergy was calculated by using fractional inhibitory and fractional lethal concentration index. DETA/NO with a half-life of 57h at 25°C showed antifungal activity against all tested dermatophyte species (MIC 0.150 to 2.5mg/ml), DPTA/NO with a half life of 3h at 37°C showed antifungal activity against five species of Candida and Cryptococcus neoformans, and DEA/NO with a half life of 2 min at 37°C and 16 min at 25°C did NOt show antifungal activity against tested strains. Combinations of DPTA-NO with either KETOCONAZOLE or AMPHOTERICIN B were either synergistic or indifferent for all tested strain of Candida and Cryptococcus neoformance. DETA/NO was unable to enhance the antifungal activity of TERBINAFINE against dermatophyte strains. Even where NO synergistic activity was achieved, there was still a decrease in the MIC of one or both drugs which were used in combination. Antagonism was observed between TERBINAFINE and DETA-NO against Trichophyton rubrum. Our result suggests that DETA/NO and DPTA/NO may be useful for development of new therapeutic strategies for treatment of dermatophyte and Candida infections. Clinical studies are warranted to elucidate the potential utility of these combination therapies.

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    Cite

    APA: Copy

    FALAHATI, M., SHABANI, M., ROODAKI, M.M.A., JAHANIANI, F., POUSHANG BAGHERI, K., & EBRAHIMI, S.A.. (2006). INTERACTION BETWEEN KETOCONAZOLE, AMPHOTERICIN B AND TERBINAFIN AND THREE DIAZENUMDIOLATES IN CONCOMITANT USES AGAINST SOME FUGAL SPECIES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 14(2), 87-92. SID. https://sid.ir/paper/275339/en

    Vancouver: Copy

    FALAHATI M., SHABANI M., ROODAKI M.M.A., JAHANIANI F., POUSHANG BAGHERI K., EBRAHIMI S.A.. INTERACTION BETWEEN KETOCONAZOLE, AMPHOTERICIN B AND TERBINAFIN AND THREE DIAZENUMDIOLATES IN CONCOMITANT USES AGAINST SOME FUGAL SPECIES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2006;14(2):87-92. Available from: https://sid.ir/paper/275339/en

    IEEE: Copy

    M. FALAHATI, M. SHABANI, M.M.A. ROODAKI, F. JAHANIANI, K. POUSHANG BAGHERI, and S.A. EBRAHIMI, “INTERACTION BETWEEN KETOCONAZOLE, AMPHOTERICIN B AND TERBINAFIN AND THREE DIAZENUMDIOLATES IN CONCOMITANT USES AGAINST SOME FUGAL SPECIES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 14, no. 2, pp. 87–92, 2006, [Online]. Available: https://sid.ir/paper/275339/en

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