THE EFFECT OF VITAMIN C SUPPLEMENTS ON GLYCATED HEMOGLOBIN IN TYPE 2 DIABETIC PATIENTS

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FORGHANI B.A.M.; KASAEIAN NAZILA; AMINI MASOUD; GOHARIYAN V.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2000 | Volume:2 | Issue:4 (SN 8) Page(s): 233-237

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Title

THE EFFECT OF VITAMIN C SUPPLEMENTS ON GLYCATED HEMOGLOBIN IN TYPE 2 DIABETIC PATIENTS

Author(s)

FORGHANI B.A.M. | KASAEIAN NAZILA | AMINI MASOUD | GOHARIYAN V. | Issue Writer Certificate

Keywords

DIABETES MELLITUS; VITAMIN C; FASTING BLOOD SUGAR; GLYCOSYLATED HEMOGLOBIN; BODY MASS INDEXQ3

Abstract

Glycated hemoglobin (HbA1C) is known as an indicator of diabetes metabolic control and glycation of proteins. There are some evidences about the role of vitamin C on inhibition of hemoglobin glycation. So, in this study, we evaluated the effect of vitamin C on glycated hemoglobin (HbA1C) level in type 2 diabetic patients. A clinical trial study was conducted on 18 type 2 diabetic patients (14 women, 4 men). We used 1000 mg supplement of vitamin C (4 250 mg) per day for 6 weeks. BMI, 3-day food records, fasting plasma glucose and glycated hemoglobin were measured before and after using vitamin C supplements. The results were analyzed by paired t-test and P<0.05 was considered significant. Glycated hemoglobin was significantly decreased at the end of the study (P<0.015). Fasting plasma sugar increased slightly but it was not statistically significant. Our results show that vitamin C, which has structural similarities with glucose, can reduce the glycosylation of hemoglobin in type 2 diabetic patients through competition with glucose. This effect can be used to control the pathogenic mechanism of protein glycation in diabetes, after more detailed studies.

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APA: Copy

FORGHANI, B.A.M., KASAEIAN, NAZILA, AMINI, MASOUD, & GOHARIYAN, V.. (2000). THE EFFECT OF VITAMIN C SUPPLEMENTS ON GLYCATED HEMOGLOBIN IN TYPE 2 DIABETIC PATIENTS . IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 2(4 (SN 8)), 233-237. SID. https://sid.ir/paper/27534/en

Vancouver: Copy

FORGHANI B.A.M., KASAEIAN NAZILA, AMINI MASOUD, GOHARIYAN V.. THE EFFECT OF VITAMIN C SUPPLEMENTS ON GLYCATED HEMOGLOBIN IN TYPE 2 DIABETIC PATIENTS . IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2000;2(4 (SN 8)):233-237. Available from: https://sid.ir/paper/27534/en

IEEE: Copy

B.A.M. FORGHANI, NAZILA KASAEIAN, MASOUD AMINI, and V. GOHARIYAN, “THE EFFECT OF VITAMIN C SUPPLEMENTS ON GLYCATED HEMOGLOBIN IN TYPE 2 DIABETIC PATIENTS ,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 2, no. 4 (SN 8), pp. 233–237, 2000, [Online]. Available: https://sid.ir/paper/27534/en

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