INTERACTION OF DIFFERENT DOSES OF ASPARTAME WITH MORPHINE-INDUCED ANTINOCICEPTION IN THE PRESENCE OF MK-801 A NMDA ANTAGONIST

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ABDOLLAHI M.; AGHABARATI F.; NIKFAR SH.; ETEMAD F.; ABDOLI N.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2002 | Volume:10 | Issue:1 Page(s): 9-16

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Title

INTERACTION OF DIFFERENT DOSES OF ASPARTAME WITH MORPHINE-INDUCED ANTINOCICEPTION IN THE PRESENCE OF MK-801 A NMDA ANTAGONIST

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Keywords

ANTINOCICEPTION

FORMALIN TEST

MORPHINE

ASPARTAME

SWEETENING AGENTS

NMDA

Abstract

This study was designed to investigate the relative role of sweetness and comparative effects of different taste sensation of the non-caloric sweetener, ASPARTAME on pain and its interaction with MK- 801 as a non-selective NMDA antagonist by formalin-test in mice. The formalin-test was chosen because it measures the response to a long-lasting nociceptive stimulus and closely resembles to the clinical pain. MORPHINE induced a dose dependent ANTINOCICEPTION in the early and late phases of FORMALIN TEST. Twelve days pretreatment of animals by ASPARTAME (0.08%, 0.16%, 0.32%) significantly potentiated MORPHINE-induced (1.5-9 mg/kg) analgesia in the early phase but significantly antagonized its analgesic effect in the late phase, dose dependently ASPARTAME (0.16%) alone showed a reduction in pain response. Naloxone (04 mg/kg) significantly antagonized the antinociceptive effect of MORPHINE in the presence of ASPARTAME (0-0.32%) in the early phase. Increasing the dose of ASPARTAME decreased effects of naloxone. MK-801 (0.1 mg/kg) as an N-Methyl-D-Aspartate (NMDA) antagonist significantly potentiated the effect of ASPARTAME on MORPHINE-induced ANTINOCICEPTION in the early phase. In the late phase, naloxone (0.4 mg/kg) increased pain response but MK-801 (0.1 mg/kg) induced antiinflammatory effect significantly. Treatment of animals with MK-801 alone, significantly induced analgesia in both phases of formalin-test. This effect was potentiated with ASPARTAME dose-dependently. Possible interaction of ASPARTAME with NMDA receptors and its role to facilitate endogenous opioid system are proposed mechanisms of ASPARTAME in modulating MORPHINE-induced ANTINOCICEPTION. Furthermore, the resulting association between MORPHINE and ASPARTAME chronic consumption may be explained as an interactive action rather than simple dose combination of both drugs.

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APA: Copy

ABDOLLAHI, M., AGHABARATI, F., NIKFAR, SH., ETEMAD, F., & ABDOLI, N.. (2002). INTERACTION OF DIFFERENT DOSES OF ASPARTAME WITH MORPHINE-INDUCED ANTINOCICEPTION IN THE PRESENCE OF MK-801 A NMDA ANTAGONIST. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 10(1), 9-16. SID. https://sid.ir/paper/275345/en

Vancouver: Copy

ABDOLLAHI M., AGHABARATI F., NIKFAR SH., ETEMAD F., ABDOLI N.. INTERACTION OF DIFFERENT DOSES OF ASPARTAME WITH MORPHINE-INDUCED ANTINOCICEPTION IN THE PRESENCE OF MK-801 A NMDA ANTAGONIST. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2002;10(1):9-16. Available from: https://sid.ir/paper/275345/en

IEEE: Copy

M. ABDOLLAHI, F. AGHABARATI, SH. NIKFAR, F. ETEMAD, and N. ABDOLI, “INTERACTION OF DIFFERENT DOSES OF ASPARTAME WITH MORPHINE-INDUCED ANTINOCICEPTION IN THE PRESENCE OF MK-801 A NMDA ANTAGONIST,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 10, no. 1, pp. 9–16, 2002, [Online]. Available: https://sid.ir/paper/275345/en

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