GLUCOCORTICOID ANTAGONIST ADMINISTRATION INTO THE BASOLATERAL AMYGDALA MODULATES PLACE AVOIDANCE MEMORY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAFAEI A.A.; RASHIDIPOUR A.; BURES J.; SHARIF M.R.; FENTON A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2000 | Volume:8 | Issue:1-2 Page(s): 30-34

Download Full-Text

View:

304

Download:

Cites:

Information Journal Paper

Title

GLUCOCORTICOID ANTAGONIST ADMINISTRATION INTO THE BASOLATERAL AMYGDALA MODULATES PLACE AVOIDANCE MEMORY

Author(s)

Keywords

BASOLATERAL AMYGDALA

PLACE AVOIDANCE LEARNING

ACQUISITION

CONSOLIDATION

RETRIEVAL

RU38486

Abstract

The present study examined the significance of glucocorticoid receptors (GRs) in the BASOLATERAL AMYGDALA (BLA) on place avoidance memory in male rats. Rats were trained to avoid footshock in a 60° segment while foraging for scattered food on a circular (80-cm diameter) arena. The rats were injected bilaterally in the BLA with the specific GR antagonist RU 38486 (3 ng dissolved in 1 ml 2% ethanol) before ACQUISITION, after training or before RETRIEVAL of the place avoidance task. Control rats were injected with vehicle. The learning in a single 30-min session was assessed 24h later by a 30 min extinction trial in which the time to first entrance and the number of entrances to the shocked area measured the avoidance memory. ACQUISITION and CONSOLIDATION were impaired when the drug was injected 10 min before training, immediately after training, or 60 min after training (P<0.01), but not 120 min after training. In contrast, injection of the antagonist before the RETRIEVAL test was ineffective (P>0.05). These findings indicate that glucocorticoids affect memory storage at least in part by binding directly to GR in the BLA and provide further evidences for the opinion that the BLA plays an important role in integrating hormonal and neurotransmitter influences on memory storage.

Cites

No record.

References

Cite

APA: Copy

VAFAEI, A.A., RASHIDIPOUR, A., BURES, J., SHARIF, M.R., & FENTON, A.. (2000). GLUCOCORTICOID ANTAGONIST ADMINISTRATION INTO THE BASOLATERAL AMYGDALA MODULATES PLACE AVOIDANCE MEMORY . DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 8(1-2), 30-34. SID. https://sid.ir/paper/275366/en

Vancouver: Copy

VAFAEI A.A., RASHIDIPOUR A., BURES J., SHARIF M.R., FENTON A.. GLUCOCORTICOID ANTAGONIST ADMINISTRATION INTO THE BASOLATERAL AMYGDALA MODULATES PLACE AVOIDANCE MEMORY . DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2000;8(1-2):30-34. Available from: https://sid.ir/paper/275366/en

IEEE: Copy

A.A. VAFAEI, A. RASHIDIPOUR, J. BURES, M.R. SHARIF, and A. FENTON, “GLUCOCORTICOID ANTAGONIST ADMINISTRATION INTO THE BASOLATERAL AMYGDALA MODULATES PLACE AVOIDANCE MEMORY ,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 8, no. 1-2, pp. 30–34, 2000, [Online]. Available: https://sid.ir/paper/275366/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops