INFLUENCE OF β- CYCLODEXTRIN COMPLEXATION ON LOVASTATIN RELEASE FROM OSMOTIC PUMP TABLETS (OPT)

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MEHRAMIZI A.; ASGARI MONFARED E.; BAYATI KH.; RAFIEI TEHRANI M.; POURFARZIB M.; DORKOUSH F.

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2007 | Volume:15 | Issue:2 Page(s): 71-78

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Title

INFLUENCE OF β- CYCLODEXTRIN COMPLEXATION ON LOVASTATIN RELEASE FROM OSMOTIC PUMP TABLETS (OPT)

Author(s)

Keywords

β-CYCLODEXTRIN

LOVASTATIN

INCLUSION COMPLEX

ELEMENTARY OSMOTIC PUMP

Abstract

An extended-release osmotic dosage form was designed and the effect of b-cyclodextrin (BCD) INCLUSION COMPLEXation on the solubility of LOVASTATIN in aqueous media was investigated. The LOVASTATIN BCD solid systems were prepared by kneading method. The ELEMENTARY OSMOTIC PUMPs (EOPs) were prepared with LOVASTATIN BCD complex with cellulose acetate (CA) and polyethylene glycol as plasticizer. The effect of the BCD molar ratio on enhancement of LOVASTATIN dissolution rate and the influences of various parameters (e.g. drug –BCD ratio, molecular weight and amount of PVP, coating weight gain) on drug release profiles were investigated. The solubility and dissolution rates of LOVASTATIN were significantly increased by using INCLUSION COMPLEXation. It was found that PVP K90 was a suitable hydrophilic polymer with thickening effect and had profoundly positive effect on drug release. The present results confirmed that dissolution rate of LOVASTATIN BCD were greatly enhanced and this system has suitable solubility behavior in EOP tablet formulations.

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APA: Copy

MEHRAMIZI, A., ASGARI MONFARED, E., BAYATI, KH., RAFIEI TEHRANI, M., POURFARZIB, M., & DORKOUSH, F.. (2007). INFLUENCE OF β- CYCLODEXTRIN COMPLEXATION ON LOVASTATIN RELEASE FROM OSMOTIC PUMP TABLETS (OPT). DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 15(2), 71-78. SID. https://sid.ir/paper/275398/en

Vancouver: Copy

MEHRAMIZI A., ASGARI MONFARED E., BAYATI KH., RAFIEI TEHRANI M., POURFARZIB M., DORKOUSH F.. INFLUENCE OF β- CYCLODEXTRIN COMPLEXATION ON LOVASTATIN RELEASE FROM OSMOTIC PUMP TABLETS (OPT). DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2007;15(2):71-78. Available from: https://sid.ir/paper/275398/en

IEEE: Copy

A. MEHRAMIZI, E. ASGARI MONFARED, KH. BAYATI, M. RAFIEI TEHRANI, M. POURFARZIB, and F. DORKOUSH, “INFLUENCE OF β- CYCLODEXTRIN COMPLEXATION ON LOVASTATIN RELEASE FROM OSMOTIC PUMP TABLETS (OPT),” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 15, no. 2, pp. 71–78, 2007, [Online]. Available: https://sid.ir/paper/275398/en

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