مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES

Pages

  9-12

Abstract

 Background and the purpose of the study: DIHYDROPYRIDINEs having carboxamides in 3 and 5 positions show anti-tuberculosis activity. The purpose of the present study was to synthesize new DHPs having possible anti-tuberculosis activity.Methods: 4,5-Dichloroimidazole-2-carboxaldehyde was condensed with N-arylacetoacetamides and ammonium acetate in methanol to give N,N-diaryl-4-(4,5-dichloroimidazole-2-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxamides. All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv).Results and major conclusion: Some of the new synthesized compounds exhibited a moderate activity in comparison to rifampicin.

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    Cite

    APA: Copy

    AMINI, MOHSEN, NAVID POUR, L., & SHAFIEI, A.. (2008). SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(1), 9-12. SID. https://sid.ir/paper/275436/en

    Vancouver: Copy

    AMINI MOHSEN, NAVID POUR L., SHAFIEI A.. SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2008;16(1):9-12. Available from: https://sid.ir/paper/275436/en

    IEEE: Copy

    MOHSEN AMINI, L. NAVID POUR, and A. SHAFIEI, “SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 16, no. 1, pp. 9–12, 2008, [Online]. Available: https://sid.ir/paper/275436/en

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