STUDY OF FORMULATION VARIABLES ON PROPERTIES OF GLIPIZIDE MUCOADHESIVE MICROSPHERES BY FACTORIAL DESIGN

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HOSMANI A.H.; KASTURE P.V.; GONJARI I.D.; KARMARKAR A.B.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2009 | Volume:17 | Issue:4 Page(s): 236-244

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Information Journal Paper

Title

STUDY OF FORMULATION VARIABLES ON PROPERTIES OF GLIPIZIDE MUCOADHESIVE MICROSPHERES BY FACTORIAL DESIGN

Author(s)

HOSMANI A.H. | KASTURE P.V. | GONJARI I.D. | KARMARKAR A.B. | Issue Writer Certificate

Keywords

POLYCARBOPHIL

FACTORIAL DESIGN

MUCOADHESIVE MICROSPHERES

GLIPIZIDE

Abstract

Background and the Purpose of the study: The purpose of the study was formulate and systemsystematic evaluation in-vitro and in-vivo behaviour of GLIPIZIDE MUCOADHESIVE MICROSPHERES using 32 full FACTORIAL DESIGN. Methods: Concentration of POLYCARBOPHIL and Sodium Alginate were selected as independent variables and the effects were checked on dependent variables like swelling index, mucoadhesion, drug entrapment efficiency and T75. In vivo studies were also performed to determine hypoglycemic activity of the MUCOADHESIVE MICROSPHERES. Results: The best batch exhibited drug entrapment efficiency of 75%, swelling index of 1.8 and mucoadhesion was 100%. The drug release from the microspheres was also sustained for more than 9 hrs. Conclusion: The concentration of POLYCARBOPHIL and sodium alginate had highly significant effects on dependent variables. In-vivo testing demonstrated a significant hypoglycemic effect of GLIPIZIDE.

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APA: Copy

HOSMANI, A.H., KASTURE, P.V., GONJARI, I.D., & KARMARKAR, A.B.. (2009). STUDY OF FORMULATION VARIABLES ON PROPERTIES OF GLIPIZIDE MUCOADHESIVE MICROSPHERES BY FACTORIAL DESIGN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 17(4), 236-244. SID. https://sid.ir/paper/275525/en

Vancouver: Copy

HOSMANI A.H., KASTURE P.V., GONJARI I.D., KARMARKAR A.B.. STUDY OF FORMULATION VARIABLES ON PROPERTIES OF GLIPIZIDE MUCOADHESIVE MICROSPHERES BY FACTORIAL DESIGN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2009;17(4):236-244. Available from: https://sid.ir/paper/275525/en

IEEE: Copy

A.H. HOSMANI, P.V. KASTURE, I.D. GONJARI, and A.B. KARMARKAR, “STUDY OF FORMULATION VARIABLES ON PROPERTIES OF GLIPIZIDE MUCOADHESIVE MICROSPHERES BY FACTORIAL DESIGN,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 17, no. 4, pp. 236–244, 2009, [Online]. Available: https://sid.ir/paper/275525/en

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