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Information Journal Paper

Title

GASTROPROTECTIVE ACTIVITY OF A-TERPINEOL IN TWO EXPERIMENTAL MODELS OF GASTRIC ULCER IN RATS

Pages

  277-281

Abstract

 Background and the purpose of the study: Several plant ESSENTIAL OILS, as well as terpenes present in ESSENTIAL OILS, have shown gastroprotective activity. The aim of the present work was to evaluate the gastroprotective activity of a-terpineol, a monoterpene alcohol which is present in ESSENTIAL OILS of various plants.Methods: The gastroprotective activity of a-terpineol was evaluated in rats by assessing the changes in ethanol and indomethacin-induced gastric ulcer scores and on gastric secretory volume and total acidity in pylorus-ligated rats. Alpha-terpineol was administrated orally at the doses of 10, 30, and 50 mg/kg one hour before administration of the ulcer inducing agents by the pylorus ligation procedure. The involvement of endogenous prostaglandins in the protective effect of a-terpineol in ethanol-induced gastric lesions test was assessed by administration of indomethacin (10 mg/kg, s.c.) 30 min before oral administration of a-terpineol at the dose of 50 mg/kg.Results:  a-terpineol presented gastroprotective activity against ethanol-induced ulcers at the doses of 10, 30, and 50 mg/kg. Epoxy-carvone at the dose of 10 mg/kg did not present gastroprotective activity against ulcer induced by indomethacin, but at the doses of 30 and 50 mg/kg it attenuated the gastric damages induced by this agent significantly. Pretreatment with indomethacin did not prevent the gastroprotective effect of a-terpineol on ethanol-induced ulcers. Alpha-terpineol also did not affect the gastric secretion in pylorus-ligated rats.Major conclusion: The results suggest that a-terpineol presents gastroprotective action which does not involve either an increase in the synthesis of endogenous prostaglandin or a decrease in the gastric acid secretion.

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    APA: Copy

    SOUZA, R.H.L., CARDOSO, M.S.P., MENEZES, C.T., SILVA, J.P., DE SOUSA, D.P., & BATISTA, J.S.. (2011). GASTROPROTECTIVE ACTIVITY OF A-TERPINEOL IN TWO EXPERIMENTAL MODELS OF GASTRIC ULCER IN RATS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 19(4), 277-281. SID. https://sid.ir/paper/275614/en

    Vancouver: Copy

    SOUZA R.H.L., CARDOSO M.S.P., MENEZES C.T., SILVA J.P., DE SOUSA D.P., BATISTA J.S.. GASTROPROTECTIVE ACTIVITY OF A-TERPINEOL IN TWO EXPERIMENTAL MODELS OF GASTRIC ULCER IN RATS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2011;19(4):277-281. Available from: https://sid.ir/paper/275614/en

    IEEE: Copy

    R.H.L. SOUZA, M.S.P. CARDOSO, C.T. MENEZES, J.P. SILVA, D.P. DE SOUSA, and J.S. BATISTA, “GASTROPROTECTIVE ACTIVITY OF A-TERPINEOL IN TWO EXPERIMENTAL MODELS OF GASTRIC ULCER IN RATS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 19, no. 4, pp. 277–281, 2011, [Online]. Available: https://sid.ir/paper/275614/en

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