DETERMINATION OF THE ROLE OF CALCIUM ON INSTABILITY OF NEUROTOXIC METABOLITE OF ECSTASY BY HPTLC-MASS

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JAMALI BARDIA; HOSSEINZADEH ARDAKANI YALDA; ROUINI MOHAMMAD REZA; FOROUMADI ALIREZA; AMIDI SALIMEH; HOSSEIN ZADEH AGHDAM VAHID; KOBARFARD FARZAD

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Journal: DARU Journal of Pharmaceutical Sciences Year:2013 | Volume:21 | Issue:1 Page(s): 0-0

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Title

DETERMINATION OF THE ROLE OF CALCIUM ON INSTABILITY OF NEUROTOXIC METABOLITE OF ECSTASY BY HPTLC-MASS

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Keywords

HHMA

HPTLC-MS

STABILITY

CALCIUM CHLORIDE

NEUROTOXICITY

Abstract

Background: Ecstasy is one of the popular illicit drugs in the world and its usage has been recently increased in Iran. This compound can destroy the serotonergic neurons and produces cognitive and psychopathology diseases. 3, 4-dihydroxymethamphetamine (HHMA) which is the main metabolite of this compound, seems to be responsible for this effect. However, no consensus has been reached among the researchers about its role. This disagreement between the researches may be due to failure in determination of HHMA as free form in physiological fluids. In this study, the STABILITY of this crucial metabolite of ecstasy was examined in different mediums.Methods: The STABILITY of HHMA was studied in the perfusion medium and water at 100 and 10 ng/mL concentrations. Moreover, the effect of temperature (0–25oC), pH (3–10), CALCIUM CHLORIDE (0–150 g/L) and ethylenediaminetetraacetic acid (EDTA) on the STABILITY of HHMA was also examined.Results: Our result suggested that the free form of HHMA could be degraded in the perfusion medium. The rate of this degradation has direct proportion to temperature (at 25oC=0.037 min-1 and at 0oC=0.002 min-1). CALCIUM CHLORIDE and sodium bicarbonate are two responsible components in this instability. Moreover, the alkaline pHs and increasing the shaking time can accelerate this effect. Although, while degradation was prevented at pH=3, EDTA could only reduce this rate about 30%.Conclusions: Calcium cation can act as an accelerator of HHMA degradation. Therefore, the perfusion medium should not contain Ca2+and the pH of medium is better to be adjusted at acidic range. Since, the internal cellular source of calcium is endoplasmic reticulum system, it can be assumed that, this cation may change HHMA and dopamine to reactive compounds that can bind covalently to the cysteinyl group of biological compounds and damage cellular components.

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APA: Copy

JAMALI, BARDIA, HOSSEINZADEH ARDAKANI, YALDA, ROUINI, MOHAMMAD REZA, FOROUMADI, ALIREZA, AMIDI, SALIMEH, HOSSEIN ZADEH AGHDAM, VAHID, & KOBARFARD, FARZAD. (2013). DETERMINATION OF THE ROLE OF CALCIUM ON INSTABILITY OF NEUROTOXIC METABOLITE OF ECSTASY BY HPTLC-MASS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(1), 0-0. SID. https://sid.ir/paper/275659/en

Vancouver: Copy

JAMALI BARDIA, HOSSEINZADEH ARDAKANI YALDA, ROUINI MOHAMMAD REZA, FOROUMADI ALIREZA, AMIDI SALIMEH, HOSSEIN ZADEH AGHDAM VAHID, KOBARFARD FARZAD. DETERMINATION OF THE ROLE OF CALCIUM ON INSTABILITY OF NEUROTOXIC METABOLITE OF ECSTASY BY HPTLC-MASS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2013;21(1):0-0. Available from: https://sid.ir/paper/275659/en

IEEE: Copy

BARDIA JAMALI, YALDA HOSSEINZADEH ARDAKANI, MOHAMMAD REZA ROUINI, ALIREZA FOROUMADI, SALIMEH AMIDI, VAHID HOSSEIN ZADEH AGHDAM, and FARZAD KOBARFARD, “DETERMINATION OF THE ROLE OF CALCIUM ON INSTABILITY OF NEUROTOXIC METABOLITE OF ECSTASY BY HPTLC-MASS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 21, no. 1, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/275659/en

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