EFFECT OF IMOD™ ON THE INFLAMMATORY PROCESS AFTER ACUTE ISCHEMIC STROKE: A RANDOMIZED CLINICAL TRIAL

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FARHOUDI MEHDI; NAJAFI NESHELI MAHDI; HASHEMILAR MAZYAR; MAHMOODPOOR ATA; SHARIFIPOUR EHSAN; BARADARAN BEHZAD; TAHERAGHDAM ALIAKBAR; SAVADI OSKOUEI DARYOUSH; SADEGHI BAZARGANI HOMAYOUN; SADEGHI HOKMABADI ELYAR; AKBARI HOSEIN; RIKHTEGAR REZA

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Journal: DARU Journal of Pharmaceutical Sciences Year:2013 | Volume:21 | Issue:3 Page(s): 0-0

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Title

EFFECT OF IMOD™ ON THE INFLAMMATORY PROCESS AFTER ACUTE ISCHEMIC STROKE: A RANDOMIZED CLINICAL TRIAL

Author(s)

Keywords

ISCHEMIC CEREBRO-VASCULAR ACCIDENT

IMOD™

INFLAMMATORY MARKERS

Abstract

Background and purpose of the study: Considering the role of inflammation in acute cerebrovascular accidents, anti-inflammatory treatment has been considered as an option in cerebrovascular diseases. Regarding the properties of Setarud (IMOD™) in immune regulation, the aim of the present study was to evaluate the role of this medication in treating patients with acute ischemic stroke.Methods: In this randomized clinical trial, 99 patients with their first ever acute ischemic stroke were divided into two groups of IMOD™ (n=49) and control (n=50). The control group underwent routine treatment and the intervention group underwent routine treatment plus daily intermittent infusion of IMOD™ (250mg on the first day and then 375mg into DW5% serum during a 30-minute period for 7 days). The serum levels of INFLAMMATORY MARKERS were evaluated on the first day (baseline) and on 4th and 7th days. Data were analyzed and the results were compared.Results and major conclusion: 58 males (58.6%) and 41 females (41.4%) with a mean age of 67.00±8.82 years, who had their first ever stroke attack, were enrolled in this trial. Treatment with IMOD™ showed a decreasing trend in IL-6 levels compared to the control group (p=0.04). In addition, the treatment resulted in the control of increasing serum levels of hsCRP after 7 days compared to the control group (p=0.02). There was an insignificant decrease in TNF-a and IL-1 levels in the IMOD™ group. Considering the prominent role of inflammation after an ischemic cerebral damage, it appears that treatment with IMOD™ improves the inflammatory profile. Therefore, IMOD™ (Setarud) might be considered as a therapeutic option in the acute ischemic stroke. However, future studies are necessary on its long-term results and clinical efficacy.

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APA: Copy

FARHOUDI, MEHDI, NAJAFI NESHELI, MAHDI, HASHEMILAR, MAZYAR, MAHMOODPOOR, ATA, SHARIFIPOUR, EHSAN, BARADARAN, BEHZAD, TAHERAGHDAM, ALIAKBAR, SAVADI OSKOUEI, DARYOUSH, SADEGHI BAZARGANI, HOMAYOUN, SADEGHI HOKMABADI, ELYAR, AKBARI, HOSEIN, & RIKHTEGAR, REZA. (2013). EFFECT OF IMOD™ ON THE INFLAMMATORY PROCESS AFTER ACUTE ISCHEMIC STROKE: A RANDOMIZED CLINICAL TRIAL. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(3), 0-0. SID. https://sid.ir/paper/275681/en

Vancouver: Copy

FARHOUDI MEHDI, NAJAFI NESHELI MAHDI, HASHEMILAR MAZYAR, MAHMOODPOOR ATA, SHARIFIPOUR EHSAN, BARADARAN BEHZAD, TAHERAGHDAM ALIAKBAR, SAVADI OSKOUEI DARYOUSH, SADEGHI BAZARGANI HOMAYOUN, SADEGHI HOKMABADI ELYAR, AKBARI HOSEIN, RIKHTEGAR REZA. EFFECT OF IMOD™ ON THE INFLAMMATORY PROCESS AFTER ACUTE ISCHEMIC STROKE: A RANDOMIZED CLINICAL TRIAL. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2013;21(3):0-0. Available from: https://sid.ir/paper/275681/en

IEEE: Copy

MEHDI FARHOUDI, MAHDI NAJAFI NESHELI, MAZYAR HASHEMILAR, ATA MAHMOODPOOR, EHSAN SHARIFIPOUR, BEHZAD BARADARAN, ALIAKBAR TAHERAGHDAM, DARYOUSH SAVADI OSKOUEI, HOMAYOUN SADEGHI BAZARGANI, ELYAR SADEGHI HOKMABADI, HOSEIN AKBARI, and REZA RIKHTEGAR, “EFFECT OF IMOD™ ON THE INFLAMMATORY PROCESS AFTER ACUTE ISCHEMIC STROKE: A RANDOMIZED CLINICAL TRIAL,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 21, no. 3, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/275681/en

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