مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

323
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

128
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE EFFECTS OF CICHORIUM INTYBUS EXTRACT ON THE MATURATION AND ACTIVITY OF DENDRITIC CELLS

Pages

  1-7

Abstract

 Background: CICHORIUM INTYBUS is a medicinal plant commonly used in traditional medicine for its benefits in immune-madiated disorders. There are several evidences showing that C. intybus can modulate immune responses.In the present study we have investigated the effects of the ethanolic root extract of this plant on the immune system by targeting DENDRITIC CELLS (DCS). For this purpose, phenotypic and functional maturity of murine DCS after treatment with the extract was analyzed by flow cytometry and mixed lymphocyte reaction (MLR) assay.Results: C. intybus did not change the expression of CD40, CD86 and MHC-II molecules as important co-stimulatory markers on DCS compared to the control, indicating that it could not promote DCS phenotypic maturation.Treatment of DCS with lower concentrations of the extract resulted in an increased production of IL-12 by these cells with no change in IL-10 release. The capacity of treated DCS to stimulate allogenic T cells proliferation and cytokines secretion was examined in the co-cuture of these cells with T cells in MLR. C. intybus at higher concentrations inhibited proliferation of allogenic T cells and in lower concentrations changed the level of cytokines such that IL-4 decreased and IFN-g increased.Conclusions: These results indicated that C. intybus extract at higher concentrations can inhibit T cell stimulating activity of DCS, whereas at lower concentrations can modulate cytokine secretion toward a Th1 pattern. These data may in part explain the traditional use of this plant in treatment of immune-mediated disorders.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    KARIMI, MOHAMMAD HOSSEIN, EBRAHIMNEZHAD, SALIMEH, NAMAYANDEH, MANDANA, & AMIRGHOFRAN, ZAHRA. (2014). THE EFFECTS OF CICHORIUM INTYBUS EXTRACT ON THE MATURATION AND ACTIVITY OF DENDRITIC CELLS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 22(2), 1-7. SID. https://sid.ir/paper/275713/en

    Vancouver: Copy

    KARIMI MOHAMMAD HOSSEIN, EBRAHIMNEZHAD SALIMEH, NAMAYANDEH MANDANA, AMIRGHOFRAN ZAHRA. THE EFFECTS OF CICHORIUM INTYBUS EXTRACT ON THE MATURATION AND ACTIVITY OF DENDRITIC CELLS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2014;22(2):1-7. Available from: https://sid.ir/paper/275713/en

    IEEE: Copy

    MOHAMMAD HOSSEIN KARIMI, SALIMEH EBRAHIMNEZHAD, MANDANA NAMAYANDEH, and ZAHRA AMIRGHOFRAN, “THE EFFECTS OF CICHORIUM INTYBUS EXTRACT ON THE MATURATION AND ACTIVITY OF DENDRITIC CELLS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 22, no. 2, pp. 1–7, 2014, [Online]. Available: https://sid.ir/paper/275713/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button