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Information Journal Paper

Title

GENOME EXPRESSION ANALYSIS BY SUPPRESSION SUBTRACTIVE HYBRIDIZATION IDENTIFIED OVEREXPRESSION OF HUMANIN, A TARGET GENE IN GASTRIC CANCER CHEMORESISTANCE

Pages

  1-7

Abstract

 Background: In cancer cells, APOPTOSIS is an important mechanism that influences the outcome of chemotherapy and the development of CHEMORESISTANCE. To find the genes involved in CHEMORESISTANCE and the development of GASTRIC CANCER, we used the SUPPRESSION SUBTRACTIVE HYBRIDIZATION method to identify the genes that are overexpressed in GASTRIC CANCER tissues compared to normal gastric tissues.Results: In the SUPPRESSION SUBTRACTIVE HYBRIDIZATION library we constructed, the most highly overexpressed genes were HUMANIN isoforms. HUMANIN is a recently identified endogenous peptide that has anti-apoptotic activity and has been selected for further study due to its potential role in the CHEMORESISTANCE of GASTRIC CANCER. Upregulation of HUMANIN isoforms was also observed in clinical samples by using quantitative real-time PCR. Among the studied isoforms, HUMANIN isoform 3, with an expression level of 4.166±1.44 fold, was the most overexpressed isoform in GC.Conclusions: The overexpression of HUMANIN in GASTRIC CANCER suggests a role for CHEMORESISTANCE and provides new insight into the biology of GASTRIC CANCER. We propose that HUMANIN isoforms are novel targets for combating CHEMORESISTANCE in GASTRIC CANCER.

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    APA: Copy

    MOTTAGHI DASTJERDI, NEGAR, SOLTANY REZAEE RAD, MOHAMMAD, SEPEHRIZADEH, ZARGHAM, ROSHANDEL, GHOLAMREZA, EBRAHIMIFARD, FARZANE, & SETAYESH, NEDA. (2014). GENOME EXPRESSION ANALYSIS BY SUPPRESSION SUBTRACTIVE HYBRIDIZATION IDENTIFIED OVEREXPRESSION OF HUMANIN, A TARGET GENE IN GASTRIC CANCER CHEMORESISTANCE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 22(1), 1-7. SID. https://sid.ir/paper/275737/en

    Vancouver: Copy

    MOTTAGHI DASTJERDI NEGAR, SOLTANY REZAEE RAD MOHAMMAD, SEPEHRIZADEH ZARGHAM, ROSHANDEL GHOLAMREZA, EBRAHIMIFARD FARZANE, SETAYESH NEDA. GENOME EXPRESSION ANALYSIS BY SUPPRESSION SUBTRACTIVE HYBRIDIZATION IDENTIFIED OVEREXPRESSION OF HUMANIN, A TARGET GENE IN GASTRIC CANCER CHEMORESISTANCE. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2014;22(1):1-7. Available from: https://sid.ir/paper/275737/en

    IEEE: Copy

    NEGAR MOTTAGHI DASTJERDI, MOHAMMAD SOLTANY REZAEE RAD, ZARGHAM SEPEHRIZADEH, GHOLAMREZA ROSHANDEL, FARZANE EBRAHIMIFARD, and NEDA SETAYESH, “GENOME EXPRESSION ANALYSIS BY SUPPRESSION SUBTRACTIVE HYBRIDIZATION IDENTIFIED OVEREXPRESSION OF HUMANIN, A TARGET GENE IN GASTRIC CANCER CHEMORESISTANCE,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 22, no. 1, pp. 1–7, 2014, [Online]. Available: https://sid.ir/paper/275737/en

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