مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ANTINOCICEPTIVE PROPERTIES OF NEW COUMARIN DERIVATIVES BEARING SUBSTITUTED 3, 4-DIHYDRO-2HBENZOTHIAZINES

Pages

  1-8

Abstract

 Background: COUMARINs are an important class of widely distributed heterocyclic natural products exhibiting a broad pharmacological profile. In this work, a new series of COUMARINs bearing substituted 3, 4-dihydro-2Hbenzothiazines were described as potential analgesic agents. The clinical use of NSAIDs as traditional analgesics is associated with side effects such as gastrointestinal lesions and nephrotoxicity. Therefore, the discovery of new safer drugs represents a challenging goal for such a research area.Results: The target compounds 3- (3-methyl-3, 4-dihydro-2H-benzo [b] [1, 4] thiazin-3-yl) -2H-chromen-2-ones 2a-u were synthesized and characterized by spectral data. The antinociceptive properties of target compounds were determined by formalin-induced test and acetic acid-induced WRITHING TEST in mice. Among the tested compounds, compound 2u bearing 2- (4- (methylsulfonyl) benzoyl) - moiety on BENZOTHIAZINE ring and 4- (methylsulfonyl) phenacyloxy- group on the 7 position of COUMARIN nucleus showed better profile of antinocecieption in both models. It was more effective than mefenamic acid during the late phase of formalin-induced test as well as in the acetic acid-induced WRITHING TEST.Conclusion: Considering the significant antinoceciptive action of phenacyloxycoumarin derivatives, compound 2u prototype might be further used as model to obtain new more potent analgesic drugs.

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    APA: Copy

    ALIPOOR, MASOOMEH, KHOOBI, MEHDI, EMAMI, SAEED, FALLAH BENAKOHAL, SAEED, GHASEMI NIRI, SEYEDEH FARNAZ, ABDOLLAHI, MOHAMMAD, FOROUMADI, ALIREZA, & SHAFIEE, ABBAS. (2014). ANTINOCICEPTIVE PROPERTIES OF NEW COUMARIN DERIVATIVES BEARING SUBSTITUTED 3, 4-DIHYDRO-2HBENZOTHIAZINES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 22(1), 1-8. SID. https://sid.ir/paper/275740/en

    Vancouver: Copy

    ALIPOOR MASOOMEH, KHOOBI MEHDI, EMAMI SAEED, FALLAH BENAKOHAL SAEED, GHASEMI NIRI SEYEDEH FARNAZ, ABDOLLAHI MOHAMMAD, FOROUMADI ALIREZA, SHAFIEE ABBAS. ANTINOCICEPTIVE PROPERTIES OF NEW COUMARIN DERIVATIVES BEARING SUBSTITUTED 3, 4-DIHYDRO-2HBENZOTHIAZINES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2014;22(1):1-8. Available from: https://sid.ir/paper/275740/en

    IEEE: Copy

    MASOOMEH ALIPOOR, MEHDI KHOOBI, SAEED EMAMI, SAEED FALLAH BENAKOHAL, SEYEDEH FARNAZ GHASEMI NIRI, MOHAMMAD ABDOLLAHI, ALIREZA FOROUMADI, and ABBAS SHAFIEE, “ANTINOCICEPTIVE PROPERTIES OF NEW COUMARIN DERIVATIVES BEARING SUBSTITUTED 3, 4-DIHYDRO-2HBENZOTHIAZINES,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 22, no. 1, pp. 1–8, 2014, [Online]. Available: https://sid.ir/paper/275740/en

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