مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EVALUATION OF IN VITRO TOXICITY OF PEPTIDE (N-ACETYL-LEU-GLY-LEU-COOH) -SUBSTITUTED-β- CYCLODEXTRIN DERIVATIVE, A NOVEL DRUG CARRIER, IN PC-12 CELLS

Pages

  1-7

Keywords

HEPTA- (N-ACETYL-LEU-GLY-LEU) -β-CD 

Abstract

 Background: Cyclodextrins (CDs) have been shown to improve physicochemical and biopharmaceutical properties of drugs when low solubility and low safety limit their use in the pharmaceutical field. Recently, a new amphiphilic peptide-substituted- b -CD, hepta- (N-acetyl-Leu-Gly-Leu) - b-CD (hepta- (N-acetyl-LGL) - b -CD), is developed which exhibited good solubility, strong inclusion ability and an appropriate average molecular weight.However, there is limited information available about its toxic effects. This study was designed to evaluate cytotoxic effects of the hepta- (N-acetyl-LGL) - b-CD (50, 200, 400, and 800 m g/ml) on rat pheochromocytoma PC-12 CELLS.Results: A significant reduction of cell viability with IC50 values of 1115.0 m/ml, 762.4 m g/ml, and 464.9 m g/ml at 6, 12, and 24 h post-treatment, respectively, as well as increased lipid peroxide levels and DNA DAMAGE were observed.Conclusions: In conclusion, hepta- (N-acetyl-Leu-Gly-Leu) - b-CD exhibit significant toxic properties at high concentrations, probably through induction of OXIDATIVE STRESS and genotoxicity.

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    APA: Copy

    SADEGHNIA, HAMID REZA, VAHDATI HASSANI, FAEZEH, SADEGHIAN, HAMID, MIANDEHI, MARYAM, HADIZADEH, FARZIN, & KARIMI, GHOLAMREZA. (2013). EVALUATION OF IN VITRO TOXICITY OF PEPTIDE (N-ACETYL-LEU-GLY-LEU-COOH) -SUBSTITUTED-β- CYCLODEXTRIN DERIVATIVE, A NOVEL DRUG CARRIER, IN PC-12 CELLS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 21(9), 1-7. SID. https://sid.ir/paper/275741/en

    Vancouver: Copy

    SADEGHNIA HAMID REZA, VAHDATI HASSANI FAEZEH, SADEGHIAN HAMID, MIANDEHI MARYAM, HADIZADEH FARZIN, KARIMI GHOLAMREZA. EVALUATION OF IN VITRO TOXICITY OF PEPTIDE (N-ACETYL-LEU-GLY-LEU-COOH) -SUBSTITUTED-β- CYCLODEXTRIN DERIVATIVE, A NOVEL DRUG CARRIER, IN PC-12 CELLS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2013;21(9):1-7. Available from: https://sid.ir/paper/275741/en

    IEEE: Copy

    HAMID REZA SADEGHNIA, FAEZEH VAHDATI HASSANI, HAMID SADEGHIAN, MARYAM MIANDEHI, FARZIN HADIZADEH, and GHOLAMREZA KARIMI, “EVALUATION OF IN VITRO TOXICITY OF PEPTIDE (N-ACETYL-LEU-GLY-LEU-COOH) -SUBSTITUTED-β- CYCLODEXTRIN DERIVATIVE, A NOVEL DRUG CARRIER, IN PC-12 CELLS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 21, no. 9, pp. 1–7, 2013, [Online]. Available: https://sid.ir/paper/275741/en

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