THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B

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ZAHED MEHR A.; DELMAGHANI S.; SHARIFIAN R.; LAK M.; ZEYNALI S.

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Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2004 | Volume:29 | Issue:1 Page(s): 26-30

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Title

THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B

Author(s)

Keywords

HEMOPHILIA B • RESTRICTION FRAGMENT LENGTH POLYMORPHISMS • FACTOR IX

Abstract

Background: Hemophilia B is an X-linked recessive coagulation disorder caused by factor IX deficiency. Analysis of factor IX gene polymorphisms is considered the best approach for prenatal diagnosis and carrier detection of hemophilia B where the identification of gene mutation is not easily possible. Objective: To study the frequency of three factor IX-linked restriction fragment length polymorphisms (RFLPs) in Iranian women.Methods: 50 normal women and 50 mothers of patients with hemophilia B entered this study. RFLP/Polymerase chain reaction (PCR) techniques for detection of BamHI, HhaI and MnlI sites were used.Results: The frequencies of DNA polymorphisms were 0.50/0.50 for HhaI; 0.24/0.76 for MnlI; and 0.02/0.98 for BamHI sites. Among 9 different haplotypes, 2 major haplotypes were predominated.Conclusion: HhaI and MnlI RFLPs can be used for carrier detection and prenatal diagnosis of hemophilia B.

Cites

GENETIC VARIATION OF RS438601 MARKER IN THE IRANIAN POPULATION: AN INFORMATIVE MARKER FOR MOLECULAR DIAGNOSIS OF HEMOPHILIA B

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APA: Copy

ZAHED MEHR, A., DELMAGHANI, S., SHARIFIAN, R., LAK, M., & ZEYNALI, S.. (2004). THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 29(1), 26-30. SID. https://sid.ir/paper/275848/en

Vancouver: Copy

ZAHED MEHR A., DELMAGHANI S., SHARIFIAN R., LAK M., ZEYNALI S.. THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2004;29(1):26-30. Available from: https://sid.ir/paper/275848/en

IEEE: Copy

A. ZAHED MEHR, S. DELMAGHANI, R. SHARIFIAN, M. LAK, and S. ZEYNALI, “THE FREQUENCIES OF THREE FACTOR IX-LINKED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN IRANIAN PATIENTS WITH HEMOPHILIA B,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 29, no. 1, pp. 26–30, 2004, [Online]. Available: https://sid.ir/paper/275848/en

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