INDICATION OF ANTI-HBC ANTIBODY SCREENING AND HBV-DNA DETECTION IN DIAGNOSING LATENT HEPATITIS B VIRUS INFECTION

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BEHZAD BEHBAHANI A.; MAFI-NEJAD A.; TABEEI S.Z.A.D.; BAGHERI LANKARANI KAMRAN; RASHIDI MAHMOUD; RASOULI MANOUCHEHR; POURABBAS B.; TORAB A.; SALAH A.R.

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Journal: Iranian Journal of Medical Sciences Year:2005 | Volume:30 | Issue:1 Page(s): 28-33

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Title

INDICATION OF ANTI-HBC ANTIBODY SCREENING AND HBV-DNA DETECTION IN DIAGNOSING LATENT HEPATITIS B VIRUS INFECTION

Author(s)

Keywords

HEPATITIS B VIRUS INFECTION. BLOOD DONORS. IRAN .ANTI-HBC. HBV-DNA

Abstract

Background: In spite of available, and sensitive screening assay for detection of hepatitis B virus surface antigen (HBsAg), occasional cases of post-transfusion hepatitis B virus infection are still observed. The aim of the present study was to assess the prevalence of positive anti hepatitis B core (anti-HBc) and presence of HBV-DNA in serum sample of healthy blood donors negative for both HBsAg and anti-HCV antibody. We evaluated whether anti-HBc could be adopted as a screening assay for blood donation. Material and Methods: Two thousands sera negative for both HBsAg and anti-HCV collected from healthy blood donors tested for presence of anti-HBc antibody. All sera positive for anti-HBc antibody were then investigated for determination of anti-HBc and anti-HBs titers, HbeAg and anti-HBe antibody by enzyme immunoassay (EIA). Every sample that tested negative for HBsAg but positive for anti-HBc alone or in combination with other serological markers was also examined for the presence of HBV-DNA by polymerase chain reaction (PCR). Results: Out of 2000 HBsAg negative blood samples, 131 samples (6.55%) were positive for anti-HBc. HBV-DNA was detected in 16 of 131(12.2%) anti-HBc positive specimens. The liver function test results were all in normal range except in 4 (25%) of 16 HBV-DNA positive subjects. Conclusion: Anti-HBc antibody should be tested routinely on blood donor volunteers, and if the sera become positive regardless of anti-HBs titer, the blood should be discarded. Further testing for HBV-DNA is appropriate to follow up the blood donor patient for HBV infection.

Cites

OCCULT HEPATITIS B VIRUS INFECTION AMONG ANTI-HBC ONLY POSITIVE INDIVIDUALS IN THE SOUTHEAST OF IRAN IN HIGH PREVALENCE OF HBV INFECTION REGION (SHORT COMMUNICATION)

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APA: Copy

BEHZAD BEHBAHANI, A., MAFI-NEJAD, A., TABEEI, S.Z.A.D., BAGHERI LANKARANI, KAMRAN, RASHIDI, MAHMOUD, RASOULI, MANOUCHEHR, POURABBAS, B., TORAB, A., & SALAH, A.R.. (2005). INDICATION OF ANTI-HBC ANTIBODY SCREENING AND HBV-DNA DETECTION IN DIAGNOSING LATENT HEPATITIS B VIRUS INFECTION. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 30(1), 28-33. SID. https://sid.ir/paper/275871/en

Vancouver: Copy

BEHZAD BEHBAHANI A., MAFI-NEJAD A., TABEEI S.Z.A.D., BAGHERI LANKARANI KAMRAN, RASHIDI MAHMOUD, RASOULI MANOUCHEHR, POURABBAS B., TORAB A., SALAH A.R.. INDICATION OF ANTI-HBC ANTIBODY SCREENING AND HBV-DNA DETECTION IN DIAGNOSING LATENT HEPATITIS B VIRUS INFECTION. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2005;30(1):28-33. Available from: https://sid.ir/paper/275871/en

IEEE: Copy

A. BEHZAD BEHBAHANI, A. MAFI-NEJAD, S.Z.A.D. TABEEI, KAMRAN BAGHERI LANKARANI, MAHMOUD RASHIDI, MANOUCHEHR RASOULI, B. POURABBAS, A. TORAB, and A.R. SALAH, “INDICATION OF ANTI-HBC ANTIBODY SCREENING AND HBV-DNA DETECTION IN DIAGNOSING LATENT HEPATITIS B VIRUS INFECTION,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 30, no. 1, pp. 28–33, 2005, [Online]. Available: https://sid.ir/paper/275871/en

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