COMPARISON OF PREDNISOLONE ALONE AND IN COMBINATION WITH AZATHIOPRINE REGIMENS IN TREATMENT OF AUTOIMMUNE HEPATITIS: A PROSPECTIVE STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

IMANIEH M.H.; KHATAMI G.; GHAVANINI A.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2000 | Volume:25 | Issue:1-2 Page(s): 67-71

Download Full-Text

View:

259

Download:

126

Cites:

Information Journal Paper

Title

COMPARISON OF PREDNISOLONE ALONE AND IN COMBINATION WITH AZATHIOPRINE REGIMENS IN TREATMENT OF AUTOIMMUNE HEPATITIS: A PROSPECTIVE STUDY

Author(s)

IMANIEH M.H. | KHATAMI G. | GHAVANINI A.A. | Issue Writer Certificate

Keywords

HEPATITIS

AUTOIMMUNE • DRUG THERAPY • PREDNISOLONE • AZATHIOPRINE

Abstract

Background: Side effects of steroid therapy of autoimmune HEPATITIS are seen more frequently with prednisolone only regimen. However, the question of efficacy restrains the broad use of prednisolone in combination with azathioprine. Objective: To compare biochemical responses to the two standard immunosuppressive drug regimens (prednisolone alone and prednisolone in combination with azathioprine) in children with autoimmune HEPATITIS. Methods: The study was performed on 42 children with autoimmune HEPATITIS. Patients were attributed to two groups, with group A receiving prednisolone alone and group B receiving prednisolone in combination with azathioprine, using simple random attribution unless there was a contraindication to azathioprine. The patients were evaluated for treatment response on three occasions: short term (one month after starting therapy), intermediate term (four to six month after starting therapy), and long term (one year after starting therapy). Chemical response was defined as decrease in aminotransferases to a level below two times the normal values and gamma globulin to lower than 2.8 g/dL. Clinical response was defined as improvement in the initial clinical signs and symptoms (jaundice, hepatomegaly, splenomegaly, fever, and edema/ascites). Results: There were no differences in chemical and clinical response rates between the two groups. Both clinical and chemical response rates in intermediate term were significantly higher than short term. However, clinical and chemical response rates in long term did not significantly differ from intermediate term. Conclusion: The study shows that some patients need time to respond to therapy. Nonetheless, it seems that whenever there is no improvement after six months of therapy, it is prudent to change the treatment regimen rather than waiting for response. With the same efficacy and less side effects, the combination regimen must be preferred as the standard regimen, unless there is a contraindication to azathioprine.

Cites

No record.

References

No record.

Cite

APA: Copy

IMANIEH, M.H., KHATAMI, G., & GHAVANINI, A.A.. (2000). COMPARISON OF PREDNISOLONE ALONE AND IN COMBINATION WITH AZATHIOPRINE REGIMENS IN TREATMENT OF AUTOIMMUNE HEPATITIS: A PROSPECTIVE STUDY. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 25(1-2), 67-71. SID. https://sid.ir/paper/275894/en

Vancouver: Copy

IMANIEH M.H., KHATAMI G., GHAVANINI A.A.. COMPARISON OF PREDNISOLONE ALONE AND IN COMBINATION WITH AZATHIOPRINE REGIMENS IN TREATMENT OF AUTOIMMUNE HEPATITIS: A PROSPECTIVE STUDY. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2000;25(1-2):67-71. Available from: https://sid.ir/paper/275894/en

IEEE: Copy

M.H. IMANIEH, G. KHATAMI, and A.A. GHAVANINI, “COMPARISON OF PREDNISOLONE ALONE AND IN COMBINATION WITH AZATHIOPRINE REGIMENS IN TREATMENT OF AUTOIMMUNE HEPATITIS: A PROSPECTIVE STUDY,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 25, no. 1-2, pp. 67–71, 2000, [Online]. Available: https://sid.ir/paper/275894/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops