PRE-ISCHEMIC TREATMENT OF PENTOXIFYLLINE REDUCES INFARCT VOLUMES IN TRANSIENT FOCAL CEREBRAL ISCHEMIA IN THE RAT

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NEKOUEIAN A.A.; VAKILI ABEDIN; DEHGHAN GHOLAM ABAS

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Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2005 | Volume:30 | Issue:4 Page(s): 169-173

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Title

PRE-ISCHEMIC TREATMENT OF PENTOXIFYLLINE REDUCES INFARCT VOLUMES IN TRANSIENT FOCAL CEREBRAL ISCHEMIA IN THE RAT

Author(s)

NEKOUEIAN A.A. | VAKILI ABEDIN | DEHGHAN GHOLAM ABAS | Issue Writer Certificate

Keywords

PENTOXIFYLLINE

CEREBRAL ISCHEMIA

TNF- ALPHA

INFARCTION

Abstract

Background: PENTOXIFYLLINE (PTX) is used in human for intermittent claudication and cerebral vascular disorders including cerebrovascular dementia. It also inhibits the synthesis of tumor necrosis factor-a (TNF-α), which is believed to be neurotoxic in animal models of CEREBRAL ISCHEMIA. The objective of this study was to examine the role of PTX on ischemia/reperfusion injures in rat model of transient focal CEREBRAL ISCHEMIA induced by middle cerebral artery occlusion (MCAO).Methods: Male Sprague Dawley rats (n=31) were assigned to sham, saline or PTX (30 or 60 mg/kg)-treated groups. Ischemia was induced by MCAO, followed by 24-hrs reperfusion.Intraperitoneal saline or PTX was administered at 30 min before ischemia. Neurological deficit score test (NOS) was performed after 24-hrs, and the animals was sacrificed for evaluation of cortical and striatal infarct volumes using triphenyltetrazolium chloride staining.Results: The sham group did not have neural dysfunction or cerebral INFARCTION. Cortical infarct volumes in 30 or 60 mg/kg PTX-treated groups, 149±12 and 129±19 mm3 respectively, were significantly lower than that of saline-treated group (208±12 mm3). Similar results were also obtained about the striatal infarct volumes (39±5 and 40±6 vs. 58±5mm3). However, there was no significant difference among the neurological dysfunctions from saline and PTX-treated rats.Conclusion: the results of this study indicate that PENTOXIFYLLINE reduced cerebral INFARCTIONs, possibly by diminishing the TNF- a-induced neurotoxicity in transient focal CEREBRAL ISCHEMIA. This finding also suggests that PENTOXIFYLLINE might be suitable for clinical trials.

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APA: Copy

NEKOUEIAN, A.A., VAKILI, ABEDIN, & DEHGHAN, GHOLAM ABAS. (2005). PRE-ISCHEMIC TREATMENT OF PENTOXIFYLLINE REDUCES INFARCT VOLUMES IN TRANSIENT FOCAL CEREBRAL ISCHEMIA IN THE RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 30(4), 169-173. SID. https://sid.ir/paper/276097/en

Vancouver: Copy

NEKOUEIAN A.A., VAKILI ABEDIN, DEHGHAN GHOLAM ABAS. PRE-ISCHEMIC TREATMENT OF PENTOXIFYLLINE REDUCES INFARCT VOLUMES IN TRANSIENT FOCAL CEREBRAL ISCHEMIA IN THE RAT. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2005;30(4):169-173. Available from: https://sid.ir/paper/276097/en

IEEE: Copy

A.A. NEKOUEIAN, ABEDIN VAKILI, and GHOLAM ABAS DEHGHAN, “PRE-ISCHEMIC TREATMENT OF PENTOXIFYLLINE REDUCES INFARCT VOLUMES IN TRANSIENT FOCAL CEREBRAL ISCHEMIA IN THE RAT,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 30, no. 4, pp. 169–173, 2005, [Online]. Available: https://sid.ir/paper/276097/en

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