ASSOCIATION OF APOLIPOPROTEIN A-IV GENE G360T POLYMORPHISM WITH METABOLIC SYNDROME: TEHRAN LIPID AND GLUCOSE STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZARKESH M.; DANESHPOUR M.; HEDAYATI M.; AZIZI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2012 | Volume:14 | Issue:1 (SN 61) Page(s): 10-17

Download Full-Text

Persian Verion

View:

732

Download:

Cites:

Information Journal Paper

Title

ASSOCIATION OF APOLIPOPROTEIN A-IV GENE G360T POLYMORPHISM WITH METABOLIC SYNDROME: TEHRAN LIPID AND GLUCOSE STUDY

Author(s)

ZARKESH M. | DANESHPOUR M. | HEDAYATI M. | AZIZI F. | Issue Writer Certificate

Keywords

POLYMORPHISM G360TQ3

APOLIPOPROTEIN A-IVQ2

HDL-CQ2

TEHRANQ2

Abstract

Introduction: Metabolic syndrome (MetS) is one of the most important risk factors for cardiovascular diseases. The aim of this study was to determine the association between the G360T polymorphism of APOLIPOPROTEIN A-IV gene and MetS.Materials and Methods: For this crosssectional study, 782 individuals, aged >19 years, were selected randomly from among TLGS participants; these included 325 men (61 with MetS and 264 controls), and 457 women (131 with MetS and 326 controls). Anthropometric and biochemical parameters were measured. The Apo A-IV gene polymorphism was studied using the PCR-RFLP method by Fnh4HI restriction enzyme.Results: Frequencies of the G and T alleles in men with MetS and those without were 85.2, 14.8, and 83.3, 16.7%, respectively, and in women with and without MetS these were 82.4, 17.6, and 85.9, 14.1%, respectively, values not significant. The GG and TT genotypes had the highest and lowest frequency, respectively (84.4% and 0.3%). Analyses of data showed that presence of T allele was significantly associated with lower levels of HDL-C (p<0.05) in women with MetS, and with lower apolipoprotein CIII levels (p<0.05) in normal women, and higher diastolic blood pressure (p<0.05) in men without MetS.Conclusion: The findings of the current study showed significant effects on HDL-C levels in women with MetS. Considering the association observed between the G360T polymorphism of Apo A-IV gene and lipid factors in women with MetS and the high prevalence of this syndrome in Iranian women, further studies recommended to assess the association of Apo AIV gene variation with lipids factors for prevention and treatment of the syndrome.

Cites

No record.

References

No record.

Cite

APA: Copy

ZARKESH, M., DANESHPOUR, M., HEDAYATI, M., & AZIZI, F.. (2012). ASSOCIATION OF APOLIPOPROTEIN A-IV GENE G360T POLYMORPHISM WITH METABOLIC SYNDROME: TEHRAN LIPID AND GLUCOSE STUDY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 14(1 (SN 61)), 10-17. SID. https://sid.ir/paper/27616/en

Vancouver: Copy

ZARKESH M., DANESHPOUR M., HEDAYATI M., AZIZI F.. ASSOCIATION OF APOLIPOPROTEIN A-IV GENE G360T POLYMORPHISM WITH METABOLIC SYNDROME: TEHRAN LIPID AND GLUCOSE STUDY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2012;14(1 (SN 61)):10-17. Available from: https://sid.ir/paper/27616/en

IEEE: Copy

M. ZARKESH, M. DANESHPOUR, M. HEDAYATI, and F. AZIZI, “ASSOCIATION OF APOLIPOPROTEIN A-IV GENE G360T POLYMORPHISM WITH METABOLIC SYNDROME: TEHRAN LIPID AND GLUCOSE STUDY,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 14, no. 1 (SN 61), pp. 10–17, 2012, [Online]. Available: https://sid.ir/paper/27616/en

Related Journal Papers