FREQUENCY OF FACTOR V LEIDEN AND PROTHROMBIN POLYMORPHISM IN SOUTH OF IRAN

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KARIMI MEHRAN; PANAHANDEH SHAHRAKI GH.R.; YAVARIAN MAJID; AFRASIABI A.A.R.; DEHBOZORGIAN J.; BORDBAR M.R.; MANNUCCI P.M.

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2009 | Volume:34 | Issue:2 Page(s): 137-140

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Title

FREQUENCY OF FACTOR V LEIDEN AND PROTHROMBIN POLYMORPHISM IN SOUTH OF IRAN

Author(s)

Keywords

FACTOR V LEIDEN

THROMBOSIS

MUTATION

PROTHROMBIN

Abstract

Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and PROTHROMBIN gene, the G20210A MUTATION, increases the resistance of factor V to degradation and booster production of PROTHROMBIN respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of these MUTATIONs in a group of the population of southern Iran. In total, 198 healthy volunteers with the age range of 1-64 years were selected and screened for FACTOR V LEIDEN and PROTHROMBIN MUTATIONs using polymerase chain reaction and restriction fragment length polymorphism techniques. The carrier frequencies for FACTOR V LEIDEN and PROTHROMBIN MUTATION in the studied cohort were 4.1% and 3.07%, respectively. In the studied area, the allele frequency of factor V is higher than the PROTHROMBIN G20210A MUTATION (0.0204 v 0.0153). According to the data and Hardy-Weinberger equation, the total risk of THROMBOSIS caused by homozygosity and heterozygosity of FACTOR V LEIDEN, PROTHROMBIN G20210A MUTATION and compound heterozygosity of these MUTATIONs are about 1 in 500 individuals.

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APA: Copy

KARIMI, MEHRAN, PANAHANDEH SHAHRAKI, GH.R., YAVARIAN, MAJID, AFRASIABI, A.A.R., DEHBOZORGIAN, J., BORDBAR, M.R., & MANNUCCI, P.M.. (2009). FREQUENCY OF FACTOR V LEIDEN AND PROTHROMBIN POLYMORPHISM IN SOUTH OF IRAN. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 34(2), 137-140. SID. https://sid.ir/paper/276271/en

Vancouver: Copy

KARIMI MEHRAN, PANAHANDEH SHAHRAKI GH.R., YAVARIAN MAJID, AFRASIABI A.A.R., DEHBOZORGIAN J., BORDBAR M.R., MANNUCCI P.M.. FREQUENCY OF FACTOR V LEIDEN AND PROTHROMBIN POLYMORPHISM IN SOUTH OF IRAN. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2009;34(2):137-140. Available from: https://sid.ir/paper/276271/en

IEEE: Copy

MEHRAN KARIMI, GH.R. PANAHANDEH SHAHRAKI, MAJID YAVARIAN, A.A.R. AFRASIABI, J. DEHBOZORGIAN, M.R. BORDBAR, and P.M. MANNUCCI, “FREQUENCY OF FACTOR V LEIDEN AND PROTHROMBIN POLYMORPHISM IN SOUTH OF IRAN,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 34, no. 2, pp. 137–140, 2009, [Online]. Available: https://sid.ir/paper/276271/en

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