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Information Journal Paper

Title

THE EFFECTS OF NDRG2 OVEREXPRESSION ON CELL PROLIFERATION AND INVASIVENESS OF SW48 COLORECTAL CANCER CELL LINE

Pages

  430-439

Abstract

 Background: Colorectal cancer (CRC) is one of the most common causes of cancer-related death in the world. The expression of N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in CRC. The aim of this study was to investigate the effect of NDRG2 overexpression on cell proliferation and invasive potential of SW48 cells.Methods: SW48 cells were transfected with a plasmid overexpressing NDRG2. After stable TRANSFECTION, the effect of NDRG2 overexpression on cell proliferation was evaluated by MTT assay. The effects of NDRG2 overexpression on cell migration, invasion and cell motility and matrix METALLOPROTEINASE 9 (MMP9) activities were also investigated using matrigel transwell assay, WOUND HEALING assay and gelatin zymography, respectively.Results: MTT assay showed that overexpression of NDRG2 caused attenuation of SW48 cell proliferation. Transwell and WOUND HEALING assay revealed that NDRG2 overexpression led to inhibition of migration, invasion, and motility of SW48 cells. The overexpression of NDRG2 also reduced the activity of secreted MMP-9.Conclusions: The results of this study suggest that NDRG2 overexpression inhibits proliferation and invasive potential of SW48 cells, which likely occurs via suppression of MMP-9 activity.

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    APA: Copy

    GOLESTAN, ALI, MOJTAHEDI, ZAHRA, GHALAMFARSA, GHASEM, HAMIDINIA, MARYAM, & TAKHSHID, MOHAMMAD ALI. (2015). THE EFFECTS OF NDRG2 OVEREXPRESSION ON CELL PROLIFERATION AND INVASIVENESS OF SW48 COLORECTAL CANCER CELL LINE. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 40(5), 430-439. SID. https://sid.ir/paper/276509/en

    Vancouver: Copy

    GOLESTAN ALI, MOJTAHEDI ZAHRA, GHALAMFARSA GHASEM, HAMIDINIA MARYAM, TAKHSHID MOHAMMAD ALI. THE EFFECTS OF NDRG2 OVEREXPRESSION ON CELL PROLIFERATION AND INVASIVENESS OF SW48 COLORECTAL CANCER CELL LINE. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2015;40(5):430-439. Available from: https://sid.ir/paper/276509/en

    IEEE: Copy

    ALI GOLESTAN, ZAHRA MOJTAHEDI, GHASEM GHALAMFARSA, MARYAM HAMIDINIA, and MOHAMMAD ALI TAKHSHID, “THE EFFECTS OF NDRG2 OVEREXPRESSION ON CELL PROLIFERATION AND INVASIVENESS OF SW48 COLORECTAL CANCER CELL LINE,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 40, no. 5, pp. 430–439, 2015, [Online]. Available: https://sid.ir/paper/276509/en

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