BRIEF REPORT: MIR-4284 AND MIR-4484 AS PUTATIVE BIOMARKERS FOR DIFFUSE LARGE B-CELL LYMPHOMA

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TAMADDON GHOLAMHOSSEIN; GERAMIZADEH BITA; KARIMI MOHAMMAD HOSSEIN; MOWLA SEYED JAVAD; ABROUN SAIED

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2016 | Volume:41 | Issue:4 Page(s): 334-339

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Title

BRIEF REPORT: MIR-4284 AND MIR-4484 AS PUTATIVE BIOMARKERS FOR DIFFUSE LARGE B-CELL LYMPHOMA

Author(s)

Keywords

LYMPHOMA

LARGE B-CELL

DIFFUSE

MICRORNAS

MICROARRAY ANALYSIS

Abstract

Diffuse LARGE B-CELL LYMPHOMA is the most common type of non- Hodgkin LYMPHOMA. MICRORNAS (miRNAs) are endogenous small RNA, which can regulate gene expression at the post-transcriptional level. MiRNA profiling has shown a great potential as novel diagnostic and prognostic biomarkers. The present study was performed at the Nemazee Teaching Hospital (Shiraz, Iran) from 2011 to 2013.The aim of this study was to assess the deregulation of miRNAs profiles in DLBL against hyperplasic reactive lymph node as a normal. This could serve as a biomarker for DLBL. The miRCURY LNATM microarray was used on the total RNA, which was extracted from formalin-fixed paraffin-embedded tissue of 24 de novo DIFFUSE LARGE B-CELL LYMPHOMA patients and 14 normal lymph nodes. The greatest changes were detected in miR-4284 and miR-4484 level in patient’s LYMPHOMA samples. These miRNAs can act as a diagnostic biomarker for DLBL.

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APA: Copy

TAMADDON, GHOLAMHOSSEIN, GERAMIZADEH, BITA, KARIMI, MOHAMMAD HOSSEIN, MOWLA, SEYED JAVAD, & ABROUN, SAIED. (2016). BRIEF REPORT: MIR-4284 AND MIR-4484 AS PUTATIVE BIOMARKERS FOR DIFFUSE LARGE B-CELL LYMPHOMA. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 41(4), 334-339. SID. https://sid.ir/paper/276545/en

Vancouver: Copy

TAMADDON GHOLAMHOSSEIN, GERAMIZADEH BITA, KARIMI MOHAMMAD HOSSEIN, MOWLA SEYED JAVAD, ABROUN SAIED. BRIEF REPORT: MIR-4284 AND MIR-4484 AS PUTATIVE BIOMARKERS FOR DIFFUSE LARGE B-CELL LYMPHOMA. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2016;41(4):334-339. Available from: https://sid.ir/paper/276545/en

IEEE: Copy

GHOLAMHOSSEIN TAMADDON, BITA GERAMIZADEH, MOHAMMAD HOSSEIN KARIMI, SEYED JAVAD MOWLA, and SAIED ABROUN, “BRIEF REPORT: MIR-4284 AND MIR-4484 AS PUTATIVE BIOMARKERS FOR DIFFUSE LARGE B-CELL LYMPHOMA,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 41, no. 4, pp. 334–339, 2016, [Online]. Available: https://sid.ir/paper/276545/en

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