THE EFFECT OF NITRIC OXIDE ON MOUSE PRE-IM PLANTATION EMBRYO DEVELOPMENT AND APOPTOSIS

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OMIDINIA E.; SOBHANI A.GH.; AMIRI I.; AKBARI M.

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Journal: Iranian Biomedical Journal Year:2003 | Volume:7 | Issue:3 Page(s): 107-112

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Title

THE EFFECT OF NITRIC OXIDE ON MOUSE PRE-IM PLANTATION EMBRYO DEVELOPMENT AND APOPTOSIS

Author(s)

OMIDINIA E. | SOBHANI A.GH. | AMIRI I. | AKBARI M. | Issue Writer Certificate

Keywords

APOPTOSIS

NITRIC OXIDE (NO)

PRE-IMPLANTATION EMBRYO

Abstract

Clinical studies have shown that in pathological conditions such as endometriosis and ‎reproductive tract infection (male and female) there is an activation status of ‎macrophages that produce large quantities of nitric oxide (NO) in addition to other ‎effector molecules. Large amounts of NO may have embryotoxic roles and produce ‎infertility. This study was designed to evaluate the effect of different concentrations ‎of NO on mouse PRE-IMPLANTATION EMBRYO development in vitro. Mouse embryos (2-‎cell stage) were cultured in media containing different concentrations of sodium ‎nitroprusside (SNP), an NO donor, or L-arginine methyl ester (L-NAME), an NO ‎syntase (NOS) inhibitor. At the end of culture, cell APOPTOSIS was studied by the ‎terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) ‎technique. The results showed that development of preimplantation embryos was ‎inhibited by high concentration of SNP (1 and 10 pM). In contrast, 0.1 pM of SNP ‎stimulated the embryo development. Similarly, the inhibition of NO by NOS inhibitor ‎resulted in the dose-dependent inhibition of embryo development, but the addition of ‎‎0.1 pM SNP with L-NAME reversed the inhibitory effect of L-NAME. TUNEL ‎technique showed that high concentration of NO could induce APOPTOSIS in the ‎embryo, but at low concentration, it decreased apoptotic cell death. Iran‏.‏

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APA: Copy

OMIDINIA, E., SOBHANI, A.GH., AMIRI, I., & AKBARI, M.. (2003). THE EFFECT OF NITRIC OXIDE ON MOUSE PRE-IM PLANTATION EMBRYO DEVELOPMENT AND APOPTOSIS. IRANIAN BIOMEDICAL JOURNAL, 7(3), 107-112. SID. https://sid.ir/paper/276960/en

Vancouver: Copy

OMIDINIA E., SOBHANI A.GH., AMIRI I., AKBARI M.. THE EFFECT OF NITRIC OXIDE ON MOUSE PRE-IM PLANTATION EMBRYO DEVELOPMENT AND APOPTOSIS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2003;7(3):107-112. Available from: https://sid.ir/paper/276960/en

IEEE: Copy

E. OMIDINIA, A.GH. SOBHANI, I. AMIRI, and M. AKBARI, “THE EFFECT OF NITRIC OXIDE ON MOUSE PRE-IM PLANTATION EMBRYO DEVELOPMENT AND APOPTOSIS,” IRANIAN BIOMEDICAL JOURNAL, vol. 7, no. 3, pp. 107–112, 2003, [Online]. Available: https://sid.ir/paper/276960/en

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