ANTICONVULSANT EFFECT OF FERULA GUMMOSA ROOT EXTRACT AGAINST EXPERIMENTAL SEIZURES

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SAYAH M.; MANDEGARI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Biomedical Journal Year:2003 | Volume:7 | Issue:3 Page(s): 139-144

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Information Journal Paper

Title

ANTICONVULSANT EFFECT OF FERULA GUMMOSA ROOT EXTRACT AGAINST EXPERIMENTAL SEIZURES

Author(s)

SAYAH M. | MANDEGARI A. | Issue Writer Certificate

Keywords

FERULA GUMMOSA

ANTICONVULSANT ACTIVITY; ROOT

ACETONE EXTRACT

Abstract

In Iranian traditional medicine, there are some reports regarding the anticonvulsant ‎effect of FERULA GUMMOSA Boiss. In this study, anticonvulsant activity, neurological ‎deficits and lethality of the root ACETONE EXTRACT of this plant were evaluated in mice. ‎The extract exhibited dose-dependent prevention of tonic seizures induced by ‎pentylenetetrazole (ED50 = 154.4 mg/kg). However, the extract produced sedation ‎and motor impairment with TD50 value of 546 mg/kg. Preliminary phytochemical ‎analysis showed the presence of terpenoids, alkaloids and a little amount of ‎cardenolids in the extract. It seems that the anticonvulsant and neurotoxic effects of ‎the extract is related in part to the terpenoid compounds. The acceptable protective ‎index of the extract (3.5) recommends further studies on FERULA GUMMOSA‏.‏

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APA: Copy

SAYAH, M., & MANDEGARI, A.. (2003). ANTICONVULSANT EFFECT OF FERULA GUMMOSA ROOT EXTRACT AGAINST EXPERIMENTAL SEIZURES. IRANIAN BIOMEDICAL JOURNAL, 7(3), 139-144. SID. https://sid.ir/paper/276961/en

Vancouver: Copy

SAYAH M., MANDEGARI A.. ANTICONVULSANT EFFECT OF FERULA GUMMOSA ROOT EXTRACT AGAINST EXPERIMENTAL SEIZURES. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2003;7(3):139-144. Available from: https://sid.ir/paper/276961/en

IEEE: Copy

M. SAYAH, and A. MANDEGARI, “ANTICONVULSANT EFFECT OF FERULA GUMMOSA ROOT EXTRACT AGAINST EXPERIMENTAL SEIZURES,” IRANIAN BIOMEDICAL JOURNAL, vol. 7, no. 3, pp. 139–144, 2003, [Online]. Available: https://sid.ir/paper/276961/en

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