MODIFICATION OF NIFEDIPINE INHIBITORY EFFECT ON CALCIUM SPIKE AND LTYPE CALCIUM CURRENT BY ETHANOL IN F1 NEURON OF HELIX ASPERSA

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JANAHMADI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Biomedical Journal Year:2003 | Volume:7 | Issue:3 Page(s): 99-106

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Title

MODIFICATION OF NIFEDIPINE INHIBITORY EFFECT ON CALCIUM SPIKE AND LTYPE CALCIUM CURRENT BY ETHANOL IN F1 NEURON OF HELIX ASPERSA

Author(s)

JANAHMADI M. | Issue Writer Certificate

Keywords

ETHANOL

NIFEDIPINE

CA^2+ SPIKES

L-TYPE CA^2+ CURRENT

F1 NEURON

Abstract

There is strong evidence demonstrating that NIFEDIPINE dissolved in ETHANOL selectively ‎inhibits only L-type Ca^2+ current. In addition, acute ETHANOL exposure reduces ‎voltage-dependent calcium currents. In the present study, we investigated the ‎antagonistic effect of fixed concentration of NIFEDIPINE dissolved in different ‎concentration of ETHANOL on L-type Ca^2+ current. In a Na^+-K^+ free solution, ‎nifedipine dissolved in 60 and 120 mM ETHANOL decreased resting membrane potential ‎of Ca^2+ spikes and caused a significant reduction in amplitude, duration and an ‎increase in threshold of Ca^2+ spikes. Furthermore, Ca^2+ current was inhibited by ‎ETHANOL in a concentration-dependent manner, so that the reduction of L-type Ca^2+ ‎current by NIFEDIPINE/60 and 120 mM ETHANOL was statistically significant. Meanwhile; ‎ETHANOL concentration-dependent response of Ca2+ currents was observed at its late ‎component in more positive potentials. These results may be consistent with ETHANOL-‎dependent inhibition of L-type Ca^2+ currents and ETHANOL-dependent enhancement of ‎a Ca^2+-activated potassium current‏.‏

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APA: Copy

JANAHMADI, M.. (2003). MODIFICATION OF NIFEDIPINE INHIBITORY EFFECT ON CALCIUM SPIKE AND LTYPE CALCIUM CURRENT BY ETHANOL IN F1 NEURON OF HELIX ASPERSA. IRANIAN BIOMEDICAL JOURNAL, 7(3), 99-106. SID. https://sid.ir/paper/276962/en

Vancouver: Copy

JANAHMADI M.. MODIFICATION OF NIFEDIPINE INHIBITORY EFFECT ON CALCIUM SPIKE AND LTYPE CALCIUM CURRENT BY ETHANOL IN F1 NEURON OF HELIX ASPERSA. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2003;7(3):99-106. Available from: https://sid.ir/paper/276962/en

IEEE: Copy

M. JANAHMADI, “MODIFICATION OF NIFEDIPINE INHIBITORY EFFECT ON CALCIUM SPIKE AND LTYPE CALCIUM CURRENT BY ETHANOL IN F1 NEURON OF HELIX ASPERSA,” IRANIAN BIOMEDICAL JOURNAL, vol. 7, no. 3, pp. 99–106, 2003, [Online]. Available: https://sid.ir/paper/276962/en

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