مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

ANTI-TUMOR ACTIVITY AND CELL CYCLE ARREST OF A NEW DITERPENE ESTER FROM DAPHNE MUCRONATA USING K562 CELLS

Pages

  127-132

Abstract

 In our search for new anticancer medicinal plants, the antiproliferative activity of the ‎methanol extract of DAPHNE MUCRONATA (Thymelaeaceae) was evaluated using human ‎myelogenous leukemia K562 cells. The cells responded to plant treatments in a dose ‎dependent manner and the IC__50 of the crude extract (equivalent to 1 g of plant ‎leaves powder per ml) and the purified active component were found to be 42 Id and ‎‎1.3 pM, respectively. The antiproliferative activity of the plant was also evaluated ‎using FLOW CYTOMETRY technique. The results indicated that the crude extract and the ‎active purified component are capable of arresting the cells in G, phase of the cell ‎progression cycle. This data may provide a mechanism for the antiproliferative action ‎of the plant

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  • Cite

    APA: Copy

    SADEGHI, HEYBAT ELAH, & YAZDAN PARAST, R.. (2003). ANTI-TUMOR ACTIVITY AND CELL CYCLE ARREST OF A NEW DITERPENE ESTER FROM DAPHNE MUCRONATA USING K562 CELLS. IRANIAN BIOMEDICAL JOURNAL, 7(3), 127-132. SID. https://sid.ir/paper/276964/en

    Vancouver: Copy

    SADEGHI HEYBAT ELAH, YAZDAN PARAST R.. ANTI-TUMOR ACTIVITY AND CELL CYCLE ARREST OF A NEW DITERPENE ESTER FROM DAPHNE MUCRONATA USING K562 CELLS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2003;7(3):127-132. Available from: https://sid.ir/paper/276964/en

    IEEE: Copy

    HEYBAT ELAH SADEGHI, and R. YAZDAN PARAST, “ANTI-TUMOR ACTIVITY AND CELL CYCLE ARREST OF A NEW DITERPENE ESTER FROM DAPHNE MUCRONATA USING K562 CELLS,” IRANIAN BIOMEDICAL JOURNAL, vol. 7, no. 3, pp. 127–132, 2003, [Online]. Available: https://sid.ir/paper/276964/en

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