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Information Journal Paper

Title

LECTIN-BINDING PATTERNS IN THE MICROENVIRONMENT OF THE MOUSE DEVELOPING T-CELLS

Pages

  19-22

Abstract

 Glycoconjugates and their programmed changes during the course of development in the cell-surface as well as in the EXTRACELLULAR MATRIX, are known to affect cell differentiation, cellular interaction and other developmental phenomena during embryogenesis. The purpose of this study was to localize N-acetylgalactosamin as well as fucose-containing glycoconjugates in situ during THYMUS development. Staged embryos or thoracic segments were fixed and processed for LECTIN HISTOCHEMISTRY studies. Five microns paraffin-embedded sections were incubated with horseradish peroxidase conjugated lectins from Dolichos biflorus and Aleuria aurantia specific for N-acetylgalactosamine and fucose, respectively. Our results revealed unique reaction of T-cells with Dolichos biflorus and the presence of a fucosylated glycoconjugate in microenvironments of the developing THYMUS including EXTRACELLULAR MATRIX and developing Hassall bodies. The time and distribution of staining with these two lectins suggest that fucosylated glycoconjugates and N-acetylgalactosamin terminal sugars may play significant role in intrathymic microenvironment that might cause differentiation of T-LYMPHOCYTES.

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    APA: Copy

    COBRA GANJI, F., & FAZEL, A.R.. (2003). LECTIN-BINDING PATTERNS IN THE MICROENVIRONMENT OF THE MOUSE DEVELOPING T-CELLS. IRANIAN BIOMEDICAL JOURNAL, 7(1), 19-22. SID. https://sid.ir/paper/276989/en

    Vancouver: Copy

    COBRA GANJI F., FAZEL A.R.. LECTIN-BINDING PATTERNS IN THE MICROENVIRONMENT OF THE MOUSE DEVELOPING T-CELLS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2003;7(1):19-22. Available from: https://sid.ir/paper/276989/en

    IEEE: Copy

    F. COBRA GANJI, and A.R. FAZEL, “LECTIN-BINDING PATTERNS IN THE MICROENVIRONMENT OF THE MOUSE DEVELOPING T-CELLS,” IRANIAN BIOMEDICAL JOURNAL, vol. 7, no. 1, pp. 19–22, 2003, [Online]. Available: https://sid.ir/paper/276989/en

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