THE EFFECT OF QUINAPRIL ON THE AORTIC CONTRACTILE RESPONSE OF STREPTOZOTOCIN-DIABETIC RATS

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ROUGHANI DEHKORDI F.; ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT

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Journal Paper

Paper Information

Journal: Iranian Biomedical Journal Year:2003 | Volume:7 | Issue:4 Page(s): 173-177

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Title

THE EFFECT OF QUINAPRIL ON THE AORTIC CONTRACTILE RESPONSE OF STREPTOZOTOCIN-DIABETIC RATS

Author(s)

ROUGHANI DEHKORDI F. | ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | Issue Writer Certificate

Keywords

QUINAPRIL

AORTIC REACTIVITY

DIABETES MELLITUS

STZ

RAT

Abstract

Angiotensin-converting enzyme (ACE) inhibitors appear to correct many of the abnormalities associated with the vascular dysfunction found in diabetic patients. In this respect, QUINAPRIL is a unique ACE inhibitor with multiple protective effects. The present study was carried out to investigate the effect of intraperitoneal administration of QUINAPRIL on the AORTIC REACTIVITY of streptozotocin (STZ)-diabetic RATs. For this purpose, male Wistar RATs received one injection of streptozotocin (STZ), 60 mg/kg, to induce diabetes. Three days after STZ injection, RATs were treated with QUINAPRIL (2 mg/kg/day) for 4 weeks, after that AORTIC REACTIVITY to vasoactive agents were compared with those of untreated diabetic RATs or non-diabetic control RATs. For this purpose, contractile response to phenylephrine (PE) was obtained from aortic rings. Concentration-response curves from QUINAPRIL-treated diabetic RATs to PE in the presence and absence of endothelium were attenuated as compared to vehicle-treated diabetics. Therefore, the 4-week treatment of diabetic RATs with QUINAPRIL could prevent the functional changes in vascular reactivity in diabetic RATs.

Cites

THE ROLE OF NITRIC OXIDE AND PROSTAGLANDINS IN THE EFFECTS OF ALCOHOLIC TRIGONELLA FOENUM-GRAECUM SEED EXTRACT ON AORTIC REACTIVITY IN STREPTOZOTOCIN-DIABETIC RATS

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APA: Copy

ROUGHANI DEHKORDI, F., ROUGHANI, M., & BALUCHNEJADMOJARAD, TOURANDOKHT. (2003). THE EFFECT OF QUINAPRIL ON THE AORTIC CONTRACTILE RESPONSE OF STREPTOZOTOCIN-DIABETIC RATS . IRANIAN BIOMEDICAL JOURNAL, 7(4), 173-177. SID. https://sid.ir/paper/276991/en

Vancouver: Copy

ROUGHANI DEHKORDI F., ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT. THE EFFECT OF QUINAPRIL ON THE AORTIC CONTRACTILE RESPONSE OF STREPTOZOTOCIN-DIABETIC RATS . IRANIAN BIOMEDICAL JOURNAL[Internet]. 2003;7(4):173-177. Available from: https://sid.ir/paper/276991/en

IEEE: Copy

F. ROUGHANI DEHKORDI, M. ROUGHANI, and TOURANDOKHT BALUCHNEJADMOJARAD, “THE EFFECT OF QUINAPRIL ON THE AORTIC CONTRACTILE RESPONSE OF STREPTOZOTOCIN-DIABETIC RATS ,” IRANIAN BIOMEDICAL JOURNAL, vol. 7, no. 4, pp. 173–177, 2003, [Online]. Available: https://sid.ir/paper/276991/en

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