DOWNREGULATION OF IL-12 PRODUCTION IN HEALTHY NON-RESPONDER NEONATES TO RECOMBINANT HEPATITIS B VACCINE

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JAFARZADEH A.; KARDAR GH.A.; KHOSHNOUDI J.; SHOKRI J.

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2004 | Volume:8 | Issue:1 Page(s): 41-45

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Information Journal Paper

Title

DOWNREGULATION OF IL-12 PRODUCTION IN HEALTHY NON-RESPONDER NEONATES TO RECOMBINANT HEPATITIS B VACCINE

Author(s)

JAFARZADEH A. | KARDAR GH.A. | KHOSHNOUDI J. | SHOKRI J. | Issue Writer Certificate

Keywords

IL-12

HEPATITIS B

VACCINATION

NEONATES

Abstract

A proportion of healthy NEONATES and adults fail to develop a protective antibody response to recombinant HEPATITIS B (HB) vaccine. Unresponsiveness to VACCINATION could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group of responder and non-responder NEONATES. Our results indicate significantly decreased production of HBsAg-induced IL-12 in non-responder subjects compared to responders (P<0.01). Since IL-12 is produced mainly by antigen presenting cells (APC) and is considered to be crucial for initiation and polarization of CD4+ T-cell function, therefore, our findings could be interpreted to imply APC dysfunction in non-responder vaccinees. Iran. Biomed.

Cites

HUMAN LEUKOCYTE ANTIGENS INFLUENCE THE ANTIBODY RESPONSE TO HEPATITIS B VACCINE (REVIEW ARTICLE)

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APA: Copy

JAFARZADEH, A., KARDAR, GH.A., KHOSHNOUDI, J., & SHOKRI, J.. (2004). DOWNREGULATION OF IL-12 PRODUCTION IN HEALTHY NON-RESPONDER NEONATES TO RECOMBINANT HEPATITIS B VACCINE. IRANIAN BIOMEDICAL JOURNAL, 8(1), 41-45. SID. https://sid.ir/paper/277006/en

Vancouver: Copy

JAFARZADEH A., KARDAR GH.A., KHOSHNOUDI J., SHOKRI J.. DOWNREGULATION OF IL-12 PRODUCTION IN HEALTHY NON-RESPONDER NEONATES TO RECOMBINANT HEPATITIS B VACCINE. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2004;8(1):41-45. Available from: https://sid.ir/paper/277006/en

IEEE: Copy

A. JAFARZADEH, GH.A. KARDAR, J. KHOSHNOUDI, and J. SHOKRI, “DOWNREGULATION OF IL-12 PRODUCTION IN HEALTHY NON-RESPONDER NEONATES TO RECOMBINANT HEPATITIS B VACCINE,” IRANIAN BIOMEDICAL JOURNAL, vol. 8, no. 1, pp. 41–45, 2004, [Online]. Available: https://sid.ir/paper/277006/en

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