ANTIEPILEPTIC POTENTIAL AND COMPOSITION OF THE FRUIT ESSENTIAL OIL OF FERULA GUMMOSA BOISS

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SAYAH M.; KAMALINEZHAD M.; ROUSTAEIAN A.A.H.; BAHRAMI HIDAGE R.

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Journal Paper

Paper Information

Journal: Iranian Biomedical Journal Year:2001 | Volume:5 | Issue:2-3 Page(s): 69-72

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Title

ANTIEPILEPTIC POTENTIAL AND COMPOSITION OF THE FRUIT ESSENTIAL OIL OF FERULA GUMMOSA BOISS

Author(s)

SAYAH M. | KAMALINEZHAD M. | ROUSTAEIAN A.A.H. | BAHRAMI HIDAGE R. | Issue Writer Certificate

Keywords

CONSTITUENTS

ESSENTIAL OIL

FERULA GUMMOSA

SEIZURE PROTECTION

Abstract

The fruit ESSENTIAL OIL of FERULA GUMMOSA boiss., Umbelliferae, which has been used as an antiepileptic remedy in Iranian traditional medicine, was evaluated for anticonvulsant activity against experimental seizures. The ESSENTIAL OIL had no effect against seizures induced by maximal electroshock. However, it protected mice against pentylenetetrazole-induced tonic seizures. The protective dose produced neurotoxicity. Moreover, this dose was too close to the LD50 of the ESSENTIAL OIL. Gas chromatography and gas chromatography-mass spectroscopy analyses of the ESSENTIAL OIL revealed the presence of β-pinene (50.1%), α-pinene (18.3%), 3-carene (6.7%), α-thujene (3.3%) and sabinene (3.1%) as the main components. The anticonvulsant and toxic effects of the ESSENTIAL OIL may be related to the compounds pinene and a-thujene respectively that present in the ESSENTIAL OIL.

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APA: Copy

SAYAH, M., KAMALINEZHAD, M., ROUSTAEIAN, A.A.H., & BAHRAMI HIDAGE, R.. (2001). ANTIEPILEPTIC POTENTIAL AND COMPOSITION OF THE FRUIT ESSENTIAL OIL OF FERULA GUMMOSA BOISS . IRANIAN BIOMEDICAL JOURNAL, 5(2-3), 69-72. SID. https://sid.ir/paper/277041/en

Vancouver: Copy

SAYAH M., KAMALINEZHAD M., ROUSTAEIAN A.A.H., BAHRAMI HIDAGE R.. ANTIEPILEPTIC POTENTIAL AND COMPOSITION OF THE FRUIT ESSENTIAL OIL OF FERULA GUMMOSA BOISS . IRANIAN BIOMEDICAL JOURNAL[Internet]. 2001;5(2-3):69-72. Available from: https://sid.ir/paper/277041/en

IEEE: Copy

M. SAYAH, M. KAMALINEZHAD, A.A.H. ROUSTAEIAN, and R. BAHRAMI HIDAGE, “ANTIEPILEPTIC POTENTIAL AND COMPOSITION OF THE FRUIT ESSENTIAL OIL OF FERULA GUMMOSA BOISS ,” IRANIAN BIOMEDICAL JOURNAL, vol. 5, no. 2-3, pp. 69–72, 2001, [Online]. Available: https://sid.ir/paper/277041/en

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