UP-REGULATION OF INTEGRINS A#2B#1 AND A#3B#1 EXPRESSION IN HUMAN FORESKIN FIBROBLAST CELLS AFTER IN-VITRO INFECTION WITH HERPES SIMPLEX VIRUS TYPE 1

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SHAH GHASEMPOUR SHAPOUR; SHAMSI SHAHOMABADI A.; FATEMINASAB F.D.; BARIN A.

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2001 | Volume:5 | Issue:2-3 Page(s): 55-59

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Title

UP-REGULATION OF INTEGRINS A#2B#1 AND A#3B#1 EXPRESSION IN HUMAN FORESKIN FIBROBLAST CELLS AFTER IN-VITRO INFECTION WITH HERPES SIMPLEX VIRUS TYPE 1

Author(s)

SHAH GHASEMPOUR SHAPOUR | SHAMSI SHAHOMABADI A. | FATEMINASAB F.D. | BARIN A. | Issue Writer Certificate

Keywords

FIBROBLASTS

HSV-1

INTEGRIN RECEPTORS

ADHESION MOLECULES

Abstract

The interaction of Herpes Simplex Virus type 1 (HSV-1) with human fetal foreskin fibroblast (HFFF) cell was studied using a recent isolate of HSV-1 which was propagated in Hep-2 cells. HFFF cells were challenged with HSV-1 with a multiplicity of infection (MOI) of 1 virus/cell for 24 hours. Flow cytometric analysis demonstrated that HSV-1 challenged HFFF cells expressed increased levels of α2β1, α3β1 (a collagen and laminin receptor) and LFA-1 (a β2 integrin, ligand for intercellular adhesion molecule-1, ICAM-1) integrins without a significant change in the expression of α5β1 (a fibronectin receptor) as compared to the mock-challenged cells. In addition, virus challenged HFFF cells showed increased expression of ICAM-1 and HLA class I antigen when compared to mock-infected cells. These results suggest that HSV-1 is capable of inducing functional changes in human foreskin fibroblast cells. The altered expression of cell-matrix and cell-cell ADHESION MOLECULES resulting from HSV-1 infection could contribute to the immunopathological diseases associated with HSV-1 infection in vivo

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APA: Copy

SHAH GHASEMPOUR, SHAPOUR, SHAMSI SHAHOMABADI, A., FATEMINASAB, F.D., & BARIN, A.. (2001). UP-REGULATION OF INTEGRINS A#2B#1 AND A#3B#1 EXPRESSION IN HUMAN FORESKIN FIBROBLAST CELLS AFTER IN-VITRO INFECTION WITH HERPES SIMPLEX VIRUS TYPE 1 . IRANIAN BIOMEDICAL JOURNAL, 5(2-3), 55-59. SID. https://sid.ir/paper/277043/en

Vancouver: Copy

SHAH GHASEMPOUR SHAPOUR, SHAMSI SHAHOMABADI A., FATEMINASAB F.D., BARIN A.. UP-REGULATION OF INTEGRINS A#2B#1 AND A#3B#1 EXPRESSION IN HUMAN FORESKIN FIBROBLAST CELLS AFTER IN-VITRO INFECTION WITH HERPES SIMPLEX VIRUS TYPE 1 . IRANIAN BIOMEDICAL JOURNAL[Internet]. 2001;5(2-3):55-59. Available from: https://sid.ir/paper/277043/en

IEEE: Copy

SHAPOUR SHAH GHASEMPOUR, A. SHAMSI SHAHOMABADI, F.D. FATEMINASAB, and A. BARIN, “UP-REGULATION OF INTEGRINS A#2B#1 AND A#3B#1 EXPRESSION IN HUMAN FORESKIN FIBROBLAST CELLS AFTER IN-VITRO INFECTION WITH HERPES SIMPLEX VIRUS TYPE 1 ,” IRANIAN BIOMEDICAL JOURNAL, vol. 5, no. 2-3, pp. 55–59, 2001, [Online]. Available: https://sid.ir/paper/277043/en

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