THE EXPRESSION OF SIGNAL REGULATORY PROTEIN-Α IN NORMAL AND OSTEOARTHRITIC HUMAN ARTICULAR CARTILAGE AND ITS INVOLVEMENT IN CHONDROCYTE MECHANO-TRANSDUCTION RESPONSE (SHORT REPORT)

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OURAZIZADEH M.; SALTER D.M.

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Journal: Iranian Biomedical Journal Year:2007 | Volume:11 | Issue:2 Page(s): 119-124

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Title

THE EXPRESSION OF SIGNAL REGULATORY PROTEIN-Α IN NORMAL AND OSTEOARTHRITIC HUMAN ARTICULAR CARTILAGE AND ITS INVOLVEMENT IN CHONDROCYTE MECHANO-TRANSDUCTION RESPONSE (SHORT REPORT)

Author(s)

OURAZIZADEH M. | SALTER D.M. | Issue Writer Certificate

Keywords

CARTILAGE

CHONDROCYTE

OSTEOARTHRITIS (OA)

SIGNAL REGULATORY PROTEINS (SIRP)

Abstract

Background: Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular CHONDROCYTEs was investigated. Methods: Using a panel of anti-SIRPa antibodies, immunohistochemistry, Western-blotting and electrophysiology methods, expression of SIRPa and its role in CHONDROCYTE mechano-transduction were assessed. Results: No identifiable positive signal was obtained by using immunohistochemistry methods on frozen and paraffin sections. SIRPa is expressed by both normal and osteoarthritis cultured CHONDROCYTEs. The electrophysiological response of CHONDROCYTEs in the presence of SE7C2 mAb was significantly inhibited whereas; SE5A5 did not show any modification in this response.Conclusions: It seems likely that SIRPa could be associated with other proteins such as integrins, CD47 and ion channels, which contribute to the electrophysiological response of human articular CHONDROCYTEs. In any case, this study has provided a specific functional role for SIRPa in CHONDROCYTE mechano-transduction.

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APA: Copy

OURAZIZADEH, M., & SALTER, D.M.. (2007). THE EXPRESSION OF SIGNAL REGULATORY PROTEIN-Α IN NORMAL AND OSTEOARTHRITIC HUMAN ARTICULAR CARTILAGE AND ITS INVOLVEMENT IN CHONDROCYTE MECHANO-TRANSDUCTION RESPONSE (SHORT REPORT). IRANIAN BIOMEDICAL JOURNAL, 11(2), 119-124. SID. https://sid.ir/paper/277141/en

Vancouver: Copy

OURAZIZADEH M., SALTER D.M.. THE EXPRESSION OF SIGNAL REGULATORY PROTEIN-Α IN NORMAL AND OSTEOARTHRITIC HUMAN ARTICULAR CARTILAGE AND ITS INVOLVEMENT IN CHONDROCYTE MECHANO-TRANSDUCTION RESPONSE (SHORT REPORT). IRANIAN BIOMEDICAL JOURNAL[Internet]. 2007;11(2):119-124. Available from: https://sid.ir/paper/277141/en

IEEE: Copy

M. OURAZIZADEH, and D.M. SALTER, “THE EXPRESSION OF SIGNAL REGULATORY PROTEIN-Α IN NORMAL AND OSTEOARTHRITIC HUMAN ARTICULAR CARTILAGE AND ITS INVOLVEMENT IN CHONDROCYTE MECHANO-TRANSDUCTION RESPONSE (SHORT REPORT),” IRANIAN BIOMEDICAL JOURNAL, vol. 11, no. 2, pp. 119–124, 2007, [Online]. Available: https://sid.ir/paper/277141/en

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