ANALYSIS OF HLA-G GENE EXPRESSION IN B-LYMPHOCYTES FROM CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS (SORT REPORT)

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REZVANI M.R.; KAZEMI A.; KAVIANI SAEID; MELLSTEDT H.; HAJFATH ALI A.

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Journal: Iranian Biomedical Journal Year:2007 | Volume:11 | Issue:2 Page(s): 125-129

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Title

ANALYSIS OF HLA-G GENE EXPRESSION IN B-LYMPHOCYTES FROM CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS (SORT REPORT)

Author(s)

Keywords

HUMAN LEUKOCYTE ANTIGEN G (HLA-G)

REVERSE TRANSCRIPTION PCR (RT)-PCR

B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA (B-CLL)

Abstract

Background: The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven HLA-G isoforms. HLA-G exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. This study it is an effort to clarify the presence of HLA-G in B-cell chronic lymphocytic leukemia (B-CLL) patients. Methods: HLA-G mRNA expression was studied in a pilot study in circulating B-CLL and also healthy controls by reverse transcription (RT)-PCR using a set of pan-HLA-G primers. Results: RT-PCR was performed on B-cells from 74 B-CLL patients and 12 healthy controls. The data showed HLA-G gene expression in 20% of the B-CLL patients. No expression of HLA-G could be detected in the healthy control group. Conclusion: These data suggest that HLA-G is expressed at the gene level in B cells from B-CLL patients but not in B cells from healthy controls. Further study is required to clarify the role of HLA-G as a regulatory factor that could affect immune response in B-CLL patients.

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APA: Copy

REZVANI, M.R., KAZEMI, A., KAVIANI, SAEID, MELLSTEDT, H., & HAJFATH ALI, A.. (2007). ANALYSIS OF HLA-G GENE EXPRESSION IN B-LYMPHOCYTES FROM CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS (SORT REPORT). IRANIAN BIOMEDICAL JOURNAL, 11(2), 125-129. SID. https://sid.ir/paper/277145/en

Vancouver: Copy

REZVANI M.R., KAZEMI A., KAVIANI SAEID, MELLSTEDT H., HAJFATH ALI A.. ANALYSIS OF HLA-G GENE EXPRESSION IN B-LYMPHOCYTES FROM CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS (SORT REPORT). IRANIAN BIOMEDICAL JOURNAL[Internet]. 2007;11(2):125-129. Available from: https://sid.ir/paper/277145/en

IEEE: Copy

M.R. REZVANI, A. KAZEMI, SAEID KAVIANI, H. MELLSTEDT, and A. HAJFATH ALI, “ANALYSIS OF HLA-G GENE EXPRESSION IN B-LYMPHOCYTES FROM CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS (SORT REPORT),” IRANIAN BIOMEDICAL JOURNAL, vol. 11, no. 2, pp. 125–129, 2007, [Online]. Available: https://sid.ir/paper/277145/en

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