SUPPRESSION OF TELOMERASE ACTIVITY BY PYRIMETHAMINE: IMPLICATION TO CANCER

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KHORAMIZADEH MOHAMMAD REZA; SAADAT F.; VAEZZADEH F.; SAFAVIFAR F.; BASHIRI H.; JAHAN SHIRI Z.; MOUMENI M.

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2007 | Volume:11 | Issue:4 Page(s): 223-228

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Title

SUPPRESSION OF TELOMERASE ACTIVITY BY PYRIMETHAMINE: IMPLICATION TO CANCER

Author(s)

Keywords

TELOMERASE

CANCER

MATRIX METALLOPROTEINASES (MMP)

PYRIMETHAMINE

Abstract

Background: Although PYRIMETHAMINE (Tindurin™) appears to be effective in the prevention and treatment of some infectious diseases, very little information exists on its unpredictable properties. We design this study to evaluate its anti-tumoral effect on a model of cell line.Methods: The cytotoxic influence of PYRIMETHAMINE on prostate cell line was investigated using an in vitro colometric assay. The potential modulatory effects on metastasis, apoptosis, and immortality characteristics of cells were assessed with gelatin zymography, terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay and telomeric repeat amplification protocol, respectively.Results: Cytotoxicity analysis of PYRIMETHAMINE revealed a dosedependent fashion. An apoptotic influence of PYRIMETHAMINE was also confirmed by data obtained from TUNEL assay. Dose-dependent inhibitory effect on matrix metalloproteinases (MMP) was seen in PYRIMETHAMINE. A potent inhibitory effect of PYRIMETHAMINE was also established by data achieved from TRAPeze TELOMERASE detection kit.Conclusions: Collectively, as induction of apoptosis together with MMP and TELOMERASE inhibition could be indicative of CANCER treatment, PYRIMETHAMINE might be considered as a chemopreventative agent in CANCER.

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APA: Copy

KHORAMIZADEH, MOHAMMAD REZA, SAADAT, F., VAEZZADEH, F., SAFAVIFAR, F., BASHIRI, H., JAHAN SHIRI, Z., MOUMENI, M.,. (2007). SUPPRESSION OF TELOMERASE ACTIVITY BY PYRIMETHAMINE: IMPLICATION TO CANCER. IRANIAN BIOMEDICAL JOURNAL, 11(4), 223-228. SID. https://sid.ir/paper/277162/en

Vancouver: Copy

KHORAMIZADEH MOHAMMAD REZA, SAADAT F., VAEZZADEH F., SAFAVIFAR F., BASHIRI H., JAHAN SHIRI Z., MOUMENI M.. SUPPRESSION OF TELOMERASE ACTIVITY BY PYRIMETHAMINE: IMPLICATION TO CANCER. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2007;11(4):223-228. Available from: https://sid.ir/paper/277162/en

IEEE: Copy

MOHAMMAD REZA KHORAMIZADEH, F. SAADAT, F. VAEZZADEH, F. SAFAVIFAR, H. BASHIRI, Z. JAHAN SHIRI, M. MOUMENI, an, “SUPPRESSION OF TELOMERASE ACTIVITY BY PYRIMETHAMINE: IMPLICATION TO CANCER,” IRANIAN BIOMEDICAL JOURNAL, vol. 11, no. 4, pp. 223–228, 2007, [Online]. Available: https://sid.ir/paper/277162/en

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