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Cites:

1

Information Journal Paper

Title

EFFECT OF PROPRANOLOL ON ANGIOGENIC FACTORS IN HUMAN HEMATOPOIETIC CELL LINESIN VITRO

Pages

  223-228

Keywords

VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) 
MATRIX METALLOPROTEINASE-2 (MMP-2) 

Abstract

 Background: Beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. Anti-tumoral, anti-inflammatory and antiangiogenesis effects of PROPRANOLOL (a non-selective beta-adrenergic blocker) have been shown. ANGIOGENESIS (replenish of the pre-existing vascular networks) plays a critical role in some pathological conditions such as tumor expansion and metastasis. In this study, we investigated the effects of PROPRANOLOL on vascular endothelial growth factor (VEGF) production and matrix metalloproteinase-2 (MMP-2) activity (two important angiogenic factors) in human leukemic cell linesin vitro.Methods: Two human leukemic T (Molt-4 and Jurkat) and one monocyte (U937) cell lines were used in this study. The cells were cultured in complete RPMI medium and then incubated with different concentrations of PROPRANOLOL (0.3-30 mM) in the presence or absence of phorbol myristate acetate (PMA, 25 ng/ml) for 48 hours. The level of VEGF secreted in the cell culture supernatants was measured with enzyme-linked immunosorbent assay kits (R and D systems) and MMP-2 activity in cell-conditioned media was evaluated by gelatin zymography.Results: PROPRANOLOL significantly decreased VEGF production and also MMP-2 activity in PMA-activated human leukemic cell lines Molt-4, Jurkat and U937 at 30 mM concentration of the drug compared to untreated control cells (P<0.05).Conclusion: PROPRANOLOL might be a useful anti-angiogenic agent in hematopoietic malignancies.Thus, PROPRANOLOL along with its chronic long-term usage in cardiac problems may have potential implication in treatment of LEUKEMIA.

Cites

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    • Cite

    APA: Copy

    HAJIGHASEMI, FATEMEH, & HAJIGHASEMI, SAKINEH. (2009). EFFECT OF PROPRANOLOL ON ANGIOGENIC FACTORS IN HUMAN HEMATOPOIETIC CELL LINESIN VITRO. IRANIAN BIOMEDICAL JOURNAL, 13(4), 223-228. SID. https://sid.ir/paper/277247/en

    Vancouver: Copy

    HAJIGHASEMI FATEMEH, HAJIGHASEMI SAKINEH. EFFECT OF PROPRANOLOL ON ANGIOGENIC FACTORS IN HUMAN HEMATOPOIETIC CELL LINESIN VITRO. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2009;13(4):223-228. Available from: https://sid.ir/paper/277247/en

    IEEE: Copy

    FATEMEH HAJIGHASEMI, and SAKINEH HAJIGHASEMI, “EFFECT OF PROPRANOLOL ON ANGIOGENIC FACTORS IN HUMAN HEMATOPOIETIC CELL LINESIN VITRO,” IRANIAN BIOMEDICAL JOURNAL, vol. 13, no. 4, pp. 223–228, 2009, [Online]. Available: https://sid.ir/paper/277247/en

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