مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

411
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

184
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

2

Information Journal Paper

Title

ANTI-INFLAMMATORY EFFECT OF THE EPIGALLOCATECHIN GALLATE FOLLOWING SPINAL CORD TRAUMA IN RAT

Pages

  31-37

Keywords

EPIGALLOCATECHIN GALLATE (EGCG) 

Abstract

 Background: Spinal cord injury (SCI) stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effects of epigallocatechin gallate (EGCG) on traumatized spinal cord.Methods: Rats were randomly divided into four groups of 12 rats each as follow: sham-operated group, trauma group, and EGCG-treatment groups (50 mg/kg, i.p., immediately and 1 hour after SCI). Spinal cord samples were taken 24 hours after injury and studied for determination of myeloperoxidase (MPO) activity, histopathological assessment and immunohistochemistry of tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b), Nitrotyrosine, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and poly(ADP-ribose) polymerase (PARP). Results: The results showed that MPO activity was significantly decreased in EGCG-treatment groups. Attenuated TNF-a, IL-1b, Nitrotyrosine, iNOS, COX-2, and PARP expression could be detected in the EGCG treated rats. Also, EGCG attenuated myelin degradation.Conclusion: On the basis of these findings, we propose that EGCG may be effective in protecting rat spinal cord from secondary damage by modulating the inflammatory reactions.

Cites

References

  • No record.

    • Cite

    APA: Copy

    KHALATBARY, ALI REZA, & AHMADVAND, HASSAN. (2011). ANTI-INFLAMMATORY EFFECT OF THE EPIGALLOCATECHIN GALLATE FOLLOWING SPINAL CORD TRAUMA IN RAT. IRANIAN BIOMEDICAL JOURNAL, 15(1-2), 31-37. SID. https://sid.ir/paper/277257/en

    Vancouver: Copy

    KHALATBARY ALI REZA, AHMADVAND HASSAN. ANTI-INFLAMMATORY EFFECT OF THE EPIGALLOCATECHIN GALLATE FOLLOWING SPINAL CORD TRAUMA IN RAT. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2011;15(1-2):31-37. Available from: https://sid.ir/paper/277257/en

    IEEE: Copy

    ALI REZA KHALATBARY, and HASSAN AHMADVAND, “ANTI-INFLAMMATORY EFFECT OF THE EPIGALLOCATECHIN GALLATE FOLLOWING SPINAL CORD TRAUMA IN RAT,” IRANIAN BIOMEDICAL JOURNAL, vol. 15, no. 1-2, pp. 31–37, 2011, [Online]. Available: https://sid.ir/paper/277257/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button