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Title

SEMI-QUANTITATIVE ANALYSIS OF HOXA11, LEUKEMIA INHIBITORY FACTOR AND BASIC TRANSCRIPTIONAL ELEMENT BINDING PROTEIN 1 MRNA EXPRESSION IN THE MID-SECRETORY ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS

Pages

  66-72

Keywords

LEUKEMIA INHIBITORY FACTOR (LIF) 
BASIC TRANSCRIPTIONAL ELEMENT BINDING PROTEIN1 (BTEB1) 

Abstract

 Background: HOXA11 and leukemia inhibitory factor (LIF) and basic transcriptional element binding protein1 (BTEB1) are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of IMPLANTATION. In this case-control study, the expression pattern of these mRNA was evaluated in patients with ENDOMETRIOSIS at the time of IMPLANTATION. We also describe a semi-quantitative RT-PCR protocol optimized in our laboratory.Methods: Eight patients with ENDOMETRIOSIS were considered as our case and 8 fertile women as control group. Expression levels of HOXA11, LIF and BTEB1 mRNA were measured in endometrium during the mid-secretory phase using semi-quantitative RT-PCR.Results: We describe the detailed procedure for the analysis ofHOXA11, LIF and BTEB1 mRNA levels. Endometrial HOXA11 and LIF mRNA expression levels (normalized to b-actin expression) were significantly decreased in endometrium of infertile patients with ENDOMETRIOSIS compared with healthy fertile controls at the time of IMPLANTATION (P<0.05). A similar trend was seen in BTEB1 mRNA expression.Conclusion: The results suggest that the alteration in expression pattern of the some genes could account for some aspects of infertility in ENDOMETRIOSIS.

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    APA: Copy

    ALIZADEH, ZOHREH, SHOKRZADEH, NASER, SAIDIJAM, MASSOUD, & FARIMANI SANOEE, MARZIEH. (2011). SEMI-QUANTITATIVE ANALYSIS OF HOXA11, LEUKEMIA INHIBITORY FACTOR AND BASIC TRANSCRIPTIONAL ELEMENT BINDING PROTEIN 1 MRNA EXPRESSION IN THE MID-SECRETORY ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS. IRANIAN BIOMEDICAL JOURNAL, 15(3), 66-72. SID. https://sid.ir/paper/277266/en

    Vancouver: Copy

    ALIZADEH ZOHREH, SHOKRZADEH NASER, SAIDIJAM MASSOUD, FARIMANI SANOEE MARZIEH. SEMI-QUANTITATIVE ANALYSIS OF HOXA11, LEUKEMIA INHIBITORY FACTOR AND BASIC TRANSCRIPTIONAL ELEMENT BINDING PROTEIN 1 MRNA EXPRESSION IN THE MID-SECRETORY ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2011;15(3):66-72. Available from: https://sid.ir/paper/277266/en

    IEEE: Copy

    ZOHREH ALIZADEH, NASER SHOKRZADEH, MASSOUD SAIDIJAM, and MARZIEH FARIMANI SANOEE, “SEMI-QUANTITATIVE ANALYSIS OF HOXA11, LEUKEMIA INHIBITORY FACTOR AND BASIC TRANSCRIPTIONAL ELEMENT BINDING PROTEIN 1 MRNA EXPRESSION IN THE MID-SECRETORY ENDOMETRIUM OF PATIENTS WITH ENDOMETRIOSIS,” IRANIAN BIOMEDICAL JOURNAL, vol. 15, no. 3, pp. 66–72, 2011, [Online]. Available: https://sid.ir/paper/277266/en

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