مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION OF ARG194TRP, ARG280HIS AND ARG399GLN POLYMORPHISMS IN X-RAY REPAIR CROSS-COMPLEMENTING GROUP 1 GENE AND RISK OF DIFFERENTIATED THYROID CARCINOMA IN IRAN

Pages

  73-78

Keywords

X-RAY REPAIR CROSS-COMPLEMENTING GROUP 1 (XRCC1) GENE 
DIFFERENTIATED THYROID CARCINOMA (DTC) 

Abstract

 Background: X-ray repair cross-complementing group 1 (XRCC1) gene is a DNA REPAIR GENE and its nonsynonymous single nucleotide polymorphisms (SNP) may influence DNA repair capacity which has been considered as a modifying risk factor for cancer development.Methods: A case-control study was conducted to investigate impact of three frequently studied polymorphisms (Arg194Trp, Arg280His and Arg399Gln) on developing differentiated thyroid carcinoma (DTC).Results: Increased risks for DTC were shown in homozygous (odds ratio (OR): 3.66, 95% confidence interval (CI): 0.38-35.60) and in dominant trait (OR: 1.22, 95% CI: 1.64-2.32) of Arg194Trp genotype. Also, for Arg280His genotype, an increased risk for DTC was shown in dominant trait (OR: 1.42, 95% confidence interval (CI): 0.76-2.68), while a mildly reduction of risk for DTC (OR: 0.77, 95% (CI): 0.50-1.17) was estimated in dominantGln genotype of Arg399Gln. Considering combinatory effects of Arg194Trpand Arg280His genotypes on DTC, the calculated OR and 95% CI for being heterozygous for one of Arg194Trpor Arg280His genotypes were 1.57 and 0.90-2.74, respectively.Conclusion: Genotyping of codons 194, 280 and 399 inXRCC1 gene may use in risk assessment of DTC.

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    APA: Copy

    FARD ESFAHANI, PEZHMAN, FARD ESFAHANI, ARMAGHAN, FAYAZ, SHIMA, GHANBARZADEH, BAHAREH, SAIDI, PARINAZ, MOHABATI, REYHANEH, BIDOKI, SEYED KAZEM, & MAJDI, MINA. (2011). ASSOCIATION OF ARG194TRP, ARG280HIS AND ARG399GLN POLYMORPHISMS IN X-RAY REPAIR CROSS-COMPLEMENTING GROUP 1 GENE AND RISK OF DIFFERENTIATED THYROID CARCINOMA IN IRAN. IRANIAN BIOMEDICAL JOURNAL, 15(3), 73-78. SID. https://sid.ir/paper/277271/en

    Vancouver: Copy

    FARD ESFAHANI PEZHMAN, FARD ESFAHANI ARMAGHAN, FAYAZ SHIMA, GHANBARZADEH BAHAREH, SAIDI PARINAZ, MOHABATI REYHANEH, BIDOKI SEYED KAZEM, MAJDI MINA. ASSOCIATION OF ARG194TRP, ARG280HIS AND ARG399GLN POLYMORPHISMS IN X-RAY REPAIR CROSS-COMPLEMENTING GROUP 1 GENE AND RISK OF DIFFERENTIATED THYROID CARCINOMA IN IRAN. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2011;15(3):73-78. Available from: https://sid.ir/paper/277271/en

    IEEE: Copy

    PEZHMAN FARD ESFAHANI, ARMAGHAN FARD ESFAHANI, SHIMA FAYAZ, BAHAREH GHANBARZADEH, PARINAZ SAIDI, REYHANEH MOHABATI, SEYED KAZEM BIDOKI, and MINA MAJDI, “ASSOCIATION OF ARG194TRP, ARG280HIS AND ARG399GLN POLYMORPHISMS IN X-RAY REPAIR CROSS-COMPLEMENTING GROUP 1 GENE AND RISK OF DIFFERENTIATED THYROID CARCINOMA IN IRAN,” IRANIAN BIOMEDICAL JOURNAL, vol. 15, no. 3, pp. 73–78, 2011, [Online]. Available: https://sid.ir/paper/277271/en

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