CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS

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MIRSHEKAR MOHAMMADALI; ROGHANI MEHRDAD; KHALILI MOHSEN; BALUCHNEJADMOJARAD TOURANDOKHT; ARAB MOAZZEN SAIEDEH

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Journal: Iranian Biomedical Journal Year:2010 | Volume:14 | Issue:1-2 Page(s): 33-39

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Title

CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS

Author(s)

Keywords

PELARGONIDIN (PG)

STREPTOZOTOCIN (STZ)

OXIDATIVE STRESS

Abstract

Background: Diabetes mellitus in some clinical cases is accompanied with hyperalgesia. In this study, we evaluated the possible beneficial effect of chronic pelargonidin (PG) treatment on hyperalgesia in streptozotocin (STZ) -diabetic neuropathic rat.Methods: Male Wistar rats (n=56) were divided into seven groups, i.e. control, diabetic, PG-treated control, PG (single- and multiple-dose) -treated diabetic, and sodium salicylate-treated control and diabetics. For induction of diabetes, STZ was injected i.p. at a single dose of 60 mg/kg. PG was orally administered at a dose of 10 mg/kg once and/or on alternate days for 8 weeks; 1 week after diabetes induction. After two months, hyperalgesia was assessed using standard formalin and hot tail immersion tests. Meanwhile, markers of OXIDATIVE STRESS in brain were measured. One-way analysis of variance was used for statistical analysis of the data.Results: Diabetic rats showed a marked chemical and thermal hyperalgesia, indicating that development of diabetic neuropathy and PG treatment (especially multiple-doses) significantly ameliorated the alteration in hyperalgesia (P<0.05-0.01) in diabetic rats as compared to untreated diabetics. PG (multiple doses) also significantly decreased diabetes-induced thiobarbituric acid reactive substances formation and non-significantly reversed elevation of nitrite level and reduction of antioxidant defensive enzyme superoxide dismutase.Conclusion: These results clearly suggest that PG prevents diabetic neuropathic hyperalgesia through attenuation of OXIDATIVE STRESS.

Cites

PELARGONIDIN IMPROVES PASSIVE AVOIDANCE TASK PERFORMANCE IN A RAT AMYLOID BETA25-35 MODEL OF ALZHEIMER’S DISEASE VIA ESTROGEN RECEPTOR INDEPENDENT PATHWAYS

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APA: Copy

MIRSHEKAR, MOHAMMADALI, ROGHANI, MEHRDAD, KHALILI, MOHSEN, BALUCHNEJADMOJARAD, TOURANDOKHT, & ARAB MOAZZEN, SAIEDEH. (2010). CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS. IRANIAN BIOMEDICAL JOURNAL, 14(1-2), 33-39. SID. https://sid.ir/paper/277295/en

Vancouver: Copy

MIRSHEKAR MOHAMMADALI, ROGHANI MEHRDAD, KHALILI MOHSEN, BALUCHNEJADMOJARAD TOURANDOKHT, ARAB MOAZZEN SAIEDEH. CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2010;14(1-2):33-39. Available from: https://sid.ir/paper/277295/en

IEEE: Copy

MOHAMMADALI MIRSHEKAR, MEHRDAD ROGHANI, MOHSEN KHALILI, TOURANDOKHT BALUCHNEJADMOJARAD, and SAIEDEH ARAB MOAZZEN, “CHRONIC ORAL PELARGONIDIN ALLEVIATES STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC HYPERALGESIA IN RAT: INVOLVEMENT OF OXIDATIVE STRESS,” IRANIAN BIOMEDICAL JOURNAL, vol. 14, no. 1-2, pp. 33–39, 2010, [Online]. Available: https://sid.ir/paper/277295/en

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