HEALING POTENTIAL OF MESENCHYMAL STEM CELLS CULTURED ON A COLLAGEN-BASED SCAFFOLD FOR SKIN REGENERATION

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SHOKRGOZAR MOHAMMAD ALI; FATTAHI MARYAM; BONAKDAR SHAHIN; RAGERDI KASHANI IRAJ; MAJIDI MOHAMMAD; HAGHIGHIPOUR NOOSHIN; BAYATI VAHID; SANATI HASSAN; SAEEDI SEYYED NASIROLDDIN

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Journal: Iranian Biomedical Journal Year:2012 | Volume:16 | Issue:2 Page(s): 68-76

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Title

HEALING POTENTIAL OF MESENCHYMAL STEM CELLS CULTURED ON A COLLAGEN-BASED SCAFFOLD FOR SKIN REGENERATION

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Keywords

TISSUE ENGINEERING

KERATINOCYTES

MESENCHYMAL STEM CELLS

Abstract

Background: Wound healing of burned skin remains a major goal in public health. Previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds.Methods: In this study, MESENCHYMAL STEM CELLS were derived from rat adipose tissues and characterized by flowcytometry. Staining methods were used to evaluate their differentiation ability. A collagen-chitosan scaffold was prepared by freeze-drying method and crosslinked by carbodiimide-based crosslinker.Results: The results of immunecytochemistry and PCR experiments confirmed the adipose-derived stem cells (ASC) in differentiation to the KERATINOCYTES under the treatment of keratinocyte growth factor. The isolated ASC were seeded on the scaffolds and implanted at the prepared wounds. The scaffolds without cells were considered as a control and implanted on the other side of the rat. Histopathological analyses confirmed the formation of new tissue on the scaffold-cell side after 14 days with the formation of dermis and epidermis.Conclusion: These results indicated the capacity of ASC in differentiation to KERATINOCYTES and also wound healing in vivo.

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APA: Copy

SHOKRGOZAR, MOHAMMAD ALI, FATTAHI, MARYAM, BONAKDAR, SHAHIN, RAGERDI KASHANI, IRAJ, MAJIDI, MOHAMMAD, HAGHIGHIPOUR, NOOSHIN, BAYATI, VAHID, SANATI, HASSAN, & SAEEDI, SEYYED NASIROLDDIN. (2012). HEALING POTENTIAL OF MESENCHYMAL STEM CELLS CULTURED ON A COLLAGEN-BASED SCAFFOLD FOR SKIN REGENERATION. IRANIAN BIOMEDICAL JOURNAL, 16(2), 68-76. SID. https://sid.ir/paper/277324/en

Vancouver: Copy

SHOKRGOZAR MOHAMMAD ALI, FATTAHI MARYAM, BONAKDAR SHAHIN, RAGERDI KASHANI IRAJ, MAJIDI MOHAMMAD, HAGHIGHIPOUR NOOSHIN, BAYATI VAHID, SANATI HASSAN, SAEEDI SEYYED NASIROLDDIN. HEALING POTENTIAL OF MESENCHYMAL STEM CELLS CULTURED ON A COLLAGEN-BASED SCAFFOLD FOR SKIN REGENERATION. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2012;16(2):68-76. Available from: https://sid.ir/paper/277324/en

IEEE: Copy

MOHAMMAD ALI SHOKRGOZAR, MARYAM FATTAHI, SHAHIN BONAKDAR, IRAJ RAGERDI KASHANI, MOHAMMAD MAJIDI, NOOSHIN HAGHIGHIPOUR, VAHID BAYATI, HASSAN SANATI, and SEYYED NASIROLDDIN SAEEDI, “HEALING POTENTIAL OF MESENCHYMAL STEM CELLS CULTURED ON A COLLAGEN-BASED SCAFFOLD FOR SKIN REGENERATION,” IRANIAN BIOMEDICAL JOURNAL, vol. 16, no. 2, pp. 68–76, 2012, [Online]. Available: https://sid.ir/paper/277324/en

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