ROLE OF XMNIγG POLYMORPHISM IN HYDROXYUREA TREATMENT AND FETAL HEMOGLOBIN LEVEL AT ISFAHANIAN INTERMEDIATE β-THALASSEMIA PATIENTS

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MOTOVALI BASHI MAJID; GHASEMI TAYYEBEH

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Journal: Iranian Biomedical Journal Year:2015 | Volume:19 | Issue:3 Page(s): 177-182

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Title

ROLE OF XMNIγG POLYMORPHISM IN HYDROXYUREA TREATMENT AND FETAL HEMOGLOBIN LEVEL AT ISFAHANIAN INTERMEDIATE β-THALASSEMIA PATIENTS

Author(s)

MOTOVALI BASHI MAJID | GHASEMI TAYYEBEH | Issue Writer Certificate

Keywords

FETAL HEMOGLOBIN (HBF)

HYDROXYUREA

INTERMEDIATE β-THALASSEMIA

Abstract

Background: b-thalassemia is the most common monogenic disorder in human. The (C®T) polymorphism at -158 upstream region of the gG - globin gene and pharmacological factors such as HYDROXYUREA have been reported to influence g-globingene expression and the severity of clinical symptoms of b-thalassemia.Methods: In the present study, 51 b-thalassemia intermediate patients were studied. Xmn1gG polymorphism genotype was determined using Tetra-Primer ARMS-PCR technique. Hemoglobin (Hb) and fetal hemoglobin (HbF) levels were determined by gel electrophoresis.Results: Of 51 patients, 35 (68.6%) patients were heterozygous (CT) and 16 (31.4%) patients were homozygous (CC). Of 30 patients under treatment by HYDROXYUREA, 20 (66.7%) patients were heterozygous (CT) and 10 (33.3%) patients were homozygous (CC). Our results demonstrated that in the heterozygous (CT) genotype, the Hb (9.58 ± 1.25 gm/dl) and HbF (89.30 ± 21.87) levels were significantly higher in comparison with homozygous (CC) genotype (7.94 ± 1.34 gm/dl and 70.32 ± 40.56, respectively). Furthermore, we observed that after drug usage, the Hb and HbF levels in patients with heterozygous (CT) genotype (0.7 ± 1.26 gm/dl and 5.95±14.8, respectively) raised more in comparison with homozygous (CC) genotype (0.26 ± 1.43 gm/dl and 0.8±1.31, respectively).Conclusion: Hb and HbF levels in the patients carrying T allele are increased significantly, and they also response to HYDROXYUREA treatment.

Cites

GENETIC DIVERSITY OF HINDIIIG POLYMORPHISM IN SECOND INTRON IVSII-I GYGENE AND ITS ASSOCIATION WITH HBF LEVEL IN β-THALASSEMIA AND INTERMEDIA THALASSEMIA IN ISFAHAN PROVINCE

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APA: Copy

MOTOVALI BASHI, MAJID, & GHASEMI, TAYYEBEH. (2015). ROLE OF XMNIγ^G POLYMORPHISM IN HYDROXYUREA TREATMENT AND FETAL HEMOGLOBIN LEVEL AT ISFAHANIAN INTERMEDIATE β-THALASSEMIA PATIENTS. IRANIAN BIOMEDICAL JOURNAL, 19(3), 177-182. SID. https://sid.ir/paper/277334/en

Vancouver: Copy

MOTOVALI BASHI MAJID, GHASEMI TAYYEBEH. ROLE OF XMNIγ^G POLYMORPHISM IN HYDROXYUREA TREATMENT AND FETAL HEMOGLOBIN LEVEL AT ISFAHANIAN INTERMEDIATE β-THALASSEMIA PATIENTS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(3):177-182. Available from: https://sid.ir/paper/277334/en

IEEE: Copy

MAJID MOTOVALI BASHI, and TAYYEBEH GHASEMI, “ROLE OF XMNIγ^G POLYMORPHISM IN HYDROXYUREA TREATMENT AND FETAL HEMOGLOBIN LEVEL AT ISFAHANIAN INTERMEDIATE β-THALASSEMIA PATIENTS,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 3, pp. 177–182, 2015, [Online]. Available: https://sid.ir/paper/277334/en

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