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Information Journal Paper

Title

IMPROVEMENT OF TISSUE SURVIVAL OF SKIN FLAPS BY 5945,-REDUCTASE INHIBITORS: POSSIBLE INVOLVEMENT OF NITRIC OXIDE AND INDUCIBLE NITRIC OXIDE SYNTHASE

Pages

  111-116

Abstract

 Background: Skin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. In a previous study, we demonstrated the beneficial effects of two 5a-reductase inhibitors, AZELAIC ACID and FINASTERIDE, on tissue survival in a rat model of skin flap grafting. In the current study, we investigated the involvement of NITRIC OXIDE and inducible NITRIC OXIDE synthase (iNOS) in graft survival mediated by these agents.Methods: A number of 42 male rats were randomly allocated into six groups: 1, normal saline topical application; 2, AZELAIC ACID (100 mg/flap); 3, FINASTERIDE (1 mg/flap); 4, injection of L-NG-nitroarginine methyl ester (L-NAME) (i.p., 20 mg/kg); 5, L-NAME (20 mg/kg, i.p.) +azelaic acid (100 mg/flap, topical); 6, L-NAME (20 mg/kg, i.p.) + FINASTERIDE (1 mg/flap, topical). Tissue survival, level of NITRIC OXIDE, and iNOS expression in groups were measured.Results: Our data revealed that AZELAIC ACID and FINASTERIDE significantly increased the expression of iNOS protein and NITRIC OXIDE (NO) levels in graft tissue (P<0.05). These increases in iNOS expression and NO level were associated with higher survival of the graft tissue.Conclusion: It appears that alterations of the NO metabolism are implicated in the AZELAIC ACID- and FINASTERIDE-mediated survival of the skin flaps.

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    APA: Copy

    KARIMI, ALI ASGHAR, AJAMI, MARJAN, ASADI, YASIN, ABOUTALEB, NAHID, GORJIPOUR, FAZEL, MALEKLOO, ROYA, & PAZOKI TOROUDI, HAMIDREZA. (2015). IMPROVEMENT OF TISSUE SURVIVAL OF SKIN FLAPS BY 5945,-REDUCTASE INHIBITORS: POSSIBLE INVOLVEMENT OF NITRIC OXIDE AND INDUCIBLE NITRIC OXIDE SYNTHASE. IRANIAN BIOMEDICAL JOURNAL, 19(2), 111-116. SID. https://sid.ir/paper/277341/en

    Vancouver: Copy

    KARIMI ALI ASGHAR, AJAMI MARJAN, ASADI YASIN, ABOUTALEB NAHID, GORJIPOUR FAZEL, MALEKLOO ROYA, PAZOKI TOROUDI HAMIDREZA. IMPROVEMENT OF TISSUE SURVIVAL OF SKIN FLAPS BY 5945,-REDUCTASE INHIBITORS: POSSIBLE INVOLVEMENT OF NITRIC OXIDE AND INDUCIBLE NITRIC OXIDE SYNTHASE. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(2):111-116. Available from: https://sid.ir/paper/277341/en

    IEEE: Copy

    ALI ASGHAR KARIMI, MARJAN AJAMI, YASIN ASADI, NAHID ABOUTALEB, FAZEL GORJIPOUR, ROYA MALEKLOO, and HAMIDREZA PAZOKI TOROUDI, “IMPROVEMENT OF TISSUE SURVIVAL OF SKIN FLAPS BY 5945,-REDUCTASE INHIBITORS: POSSIBLE INVOLVEMENT OF NITRIC OXIDE AND INDUCIBLE NITRIC OXIDE SYNTHASE,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 2, pp. 111–116, 2015, [Online]. Available: https://sid.ir/paper/277341/en

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