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Information Journal Paper

Title

MESENCHYMAL STEM CELLS AS AN ALTERNATIVE FOR SCHWANN CELLS IN RAT SPINAL CORD INJURY

Pages

  113-122

Keywords

SPINAL CORD INJURIES (SCI) 

Abstract

 Background: Spinal cord has a limited capacity to repair; therefore, medical interventions are necessary for treatment of injuries. Transplantation of SCHWANN CELLS has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity.Furthermore, accessible sources such as BONE MARROW stem cells have drawn attentions to themselves. Therefore, this study was designed to evaluate the effect of BONE MARROW-derived Schwann cell on functional recovery in adult RATS after injury.Methods: Mesenchymal stem cells were cultured from adult RATS’ BONE MARROW and induced into SCHWANN CELLS in vitro. Differentiation was confirmed by immunocytochemistry and RT-PCR. Next, SCHWANN CELLS were seeded into collagen scaffolds and engrafted in 3 mm lateral hemisection defects. For 8 weeks, motor and sensory improvements were assessed by open field locomotor scale, narrow beam, and tail flick tests. Afterwards, lesioned spinal cord was evaluated by conventional histology and immunohistochemistry.Results: In vitro observations showed that differentiated cells had Schwann cell morphology and markers. In this study, we had four groups (n=10 each): laminectomy, control, scaffold and scaffold+Schwann cells. Locomotor and sensory scores of cell grafted group were significantly better than control and scaffold groups. In histology, axonal regeneration and remyelination were better than control and scaffold groups.Conclusion: This study demonstrates that BONE MARROW-derived SCHWANN CELLS can be considered as a cell source for SCHWANN CELLS in SCI treatment.

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    APA: Copy

    ZAMINY, ARASH, SHOKRGOZAR, MOHAMMAD ALI, SADEGHI, YOUSEF, NOROOZIAN, MOHSEN, HEIDARI, MOHAMMAD HASAN, & PIRYAEI, ABBAS. (2013). MESENCHYMAL STEM CELLS AS AN ALTERNATIVE FOR SCHWANN CELLS IN RAT SPINAL CORD INJURY. IRANIAN BIOMEDICAL JOURNAL, 17(3), 113-122. SID. https://sid.ir/paper/277378/en

    Vancouver: Copy

    ZAMINY ARASH, SHOKRGOZAR MOHAMMAD ALI, SADEGHI YOUSEF, NOROOZIAN MOHSEN, HEIDARI MOHAMMAD HASAN, PIRYAEI ABBAS. MESENCHYMAL STEM CELLS AS AN ALTERNATIVE FOR SCHWANN CELLS IN RAT SPINAL CORD INJURY. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2013;17(3):113-122. Available from: https://sid.ir/paper/277378/en

    IEEE: Copy

    ARASH ZAMINY, MOHAMMAD ALI SHOKRGOZAR, YOUSEF SADEGHI, MOHSEN NOROOZIAN, MOHAMMAD HASAN HEIDARI, and ABBAS PIRYAEI, “MESENCHYMAL STEM CELLS AS AN ALTERNATIVE FOR SCHWANN CELLS IN RAT SPINAL CORD INJURY,” IRANIAN BIOMEDICAL JOURNAL, vol. 17, no. 3, pp. 113–122, 2013, [Online]. Available: https://sid.ir/paper/277378/en

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