QUANTITATIVE ASSESSMENT OF PROLIFERATIVE EFFECTS OF ORAL VANADIUM ON PANCREATIC ISLET VOLUMES AND BETA CELL NUMBERS OF DIABETIC RATS

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PIRMORADI LEILA; NOORAFSHAN ALI; SAFAEE AKBAR; DEHGHANI GHOLAM ABBAS

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Journal: Iranian Biomedical Journal Year:2016 | Volume:20 | Issue:1 Page(s): 18-25

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Title

QUANTITATIVE ASSESSMENT OF PROLIFERATIVE EFFECTS OF ORAL VANADIUM ON PANCREATIC ISLET VOLUMES AND BETA CELL NUMBERS OF DIABETIC RATS

Author(s)

PIRMORADI LEILA | NOORAFSHAN ALI | SAFAEE AKBAR | DEHGHANI GHOLAM ABBAS | Issue Writer Certificate

Keywords

VANADIUM

PANCREAS

ISLET VOLUMES

RATS

Abstract

Background: Oral vanadyl sulfate (VANADIUM) induces normoglycemia, proliferates beta cells and prevents pancreatic islet atrophy in streptozotocin-induced diabetic RATS. Soteriological method is used to quantitate the proliferative effects of VANADIUM on beta-cell numbers and ISLET VOLUMES of normal and diabetic RATS. Methods: Adult male Sprague-Dawley RATS were made diabetic with intravenous streptozotocin injection (40 mg/kg). Normal and diabetic RATS were divided into four groups. While control normal and diabetic (CD) groups used water, VANADIUM-treated normal (VTN) and diabetic (VTD) groups used solu ons containing vanadyl sulfate (0.51 mg/mL, VOSO4+5H2O). Tail blood samples were used to measure blood glucose (BG) and plasma insulin. Two months after treatment, RATS were sacrificed, pancreata prepared, and stereology method was used to quantitatively evaluate total beta cell numbers (TBCN) and total ISLET VOLUMES (TISVOL). Results: Normoglycemia persisted in VTN with significantly decreased plasma insulin (0.19±0.08 vs. 0.97±0.27 ng/dL, P<0.002). The respect ve high BG (532±49 vs. 144±46 mg/dL, P<0.0001) and reduced plasma insulin (0.26±0.15 vs. 0.54±0.19 ng/dL, P<0.002) seen in CD were reversed in VTD during VANADIUM treatment or withdrawal. While the induction of diabetes, compared to their control, significantly decreased TISVOL (1.9±0.2 vs. 3.03±0.6 mm3, P<0.003) and TBCN (0.99±0.1 vs. 3.2±0.2 x 106, P<0.003), VANADIUM treatment significantly increased TISVOL (2.9±0.8 and 4.07±1.0 mm3, P<0.003) and TBCN (1.5±0.3 and 3.8±0.6 x 106, P<0.03). Conclusion: Two-month oral VANADIUM therapy in STZ-diabetic RATS ameliorated hyperglycemia by partially restoring plasma insulin. This action was through proliferative actions of VANADIUM in preventing islet atrophy by increasing beta-cell numbers.

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References

DOES THE RELIEF OF GLUCOSE TOXICITY ACT AS A MEDIATOR IN PROLIFERATIVE ACTIONS OF VANADIUM ON PANCREATIC ISLET BETA CELLS IN STREPTOZOCIN DIABETIC RATS?

Cite

APA: Copy

PIRMORADI, LEILA, NOORAFSHAN, ALI, SAFAEE, AKBAR, & DEHGHANI, GHOLAM ABBAS. (2016). QUANTITATIVE ASSESSMENT OF PROLIFERATIVE EFFECTS OF ORAL VANADIUM ON PANCREATIC ISLET VOLUMES AND BETA CELL NUMBERS OF DIABETIC RATS. IRANIAN BIOMEDICAL JOURNAL, 20(1), 18-25. SID. https://sid.ir/paper/277432/en

Vancouver: Copy

PIRMORADI LEILA, NOORAFSHAN ALI, SAFAEE AKBAR, DEHGHANI GHOLAM ABBAS. QUANTITATIVE ASSESSMENT OF PROLIFERATIVE EFFECTS OF ORAL VANADIUM ON PANCREATIC ISLET VOLUMES AND BETA CELL NUMBERS OF DIABETIC RATS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2016;20(1):18-25. Available from: https://sid.ir/paper/277432/en

IEEE: Copy

LEILA PIRMORADI, ALI NOORAFSHAN, AKBAR SAFAEE, and GHOLAM ABBAS DEHGHANI, “QUANTITATIVE ASSESSMENT OF PROLIFERATIVE EFFECTS OF ORAL VANADIUM ON PANCREATIC ISLET VOLUMES AND BETA CELL NUMBERS OF DIABETIC RATS,” IRANIAN BIOMEDICAL JOURNAL, vol. 20, no. 1, pp. 18–25, 2016, [Online]. Available: https://sid.ir/paper/277432/en

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