مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

389
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

284
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CHLORPROMAZINE-INDUCED HYPERPROLACTINEMIA ON RAT’S UTERUS

Pages

  226-232

Abstract

 Background: HYPERPROLACTINEMIA is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in RATS. Moreover, the mammary glands were analyzed to show HYPERPROLACTINEMIA-induced histological changes. Methods: Albino Wistar RATS (n = 32) were divided into four groups. The first group was set as a control. In the three drug-treated groups (eight RATS in each group), CPZ was administered by a gavage at doses of 3, 10, and 30 mg/kg/day for 28 days. One day after the last administration of the drug, the animals were sacrificed. Histopathological and histomorphometrical analyses of the uterine horns and mammary glands were carried out to evaluate dose-dependent effect of CPZ on histological structure. Serum levels of prolactin (PRL), estradiol, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were also evaluated. Results: Remarkable (P < 0.05) elevation was observed in CPZ-administrated animals’ uterine horn endometrium, myometrium, and perimetrium thicknesses, and the mammary glands were observed with galactorrhea features. The serum level of progesterone and PRL significantly (P < 0.05) increased, while the serum concentration of LH, FSH, and estradiol was notably (P < 0.05) decreased depending on administrated CPZ dose. No histological and biological changes were occurred in the control animals. Conclusion: The present findings suggest that CPZ-induced disturbances not only depend on PRL level and increased PRL level largely depends on administrated doses of the CPZ.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    ZAMANI, ZAHRA, ZARE, SAMAD, SADRKHANLOU, RAJABALI, AHMADI, ABBAS, & MOVAHED, ELHAM. (2015). CHLORPROMAZINE-INDUCED HYPERPROLACTINEMIA ON RAT’S UTERUS. IRANIAN BIOMEDICAL JOURNAL, 19(4), 226-232. SID. https://sid.ir/paper/277441/en

    Vancouver: Copy

    ZAMANI ZAHRA, ZARE SAMAD, SADRKHANLOU RAJABALI, AHMADI ABBAS, MOVAHED ELHAM. CHLORPROMAZINE-INDUCED HYPERPROLACTINEMIA ON RAT’S UTERUS. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(4):226-232. Available from: https://sid.ir/paper/277441/en

    IEEE: Copy

    ZAHRA ZAMANI, SAMAD ZARE, RAJABALI SADRKHANLOU, ABBAS AHMADI, and ELHAM MOVAHED, “CHLORPROMAZINE-INDUCED HYPERPROLACTINEMIA ON RAT’S UTERUS,” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 4, pp. 226–232, 2015, [Online]. Available: https://sid.ir/paper/277441/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button