PROTECTIVE ROLE OF OLEUROPEIN AGAINST ACUTE DELTAMETHRIN- INDUCED NEUROTOXICITY IN RAT BRAIN (SHORT COMMUNICATION)

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KHALATBARY ALI REZA; GHAFFARI ELMIRA; MOHAMMADNEGAD BEHROOZ

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2015 | Volume:19 | Issue:4 Page(s): 247-253

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Information Journal Paper

Title

PROTECTIVE ROLE OF OLEUROPEIN AGAINST ACUTE DELTAMETHRIN- INDUCED NEUROTOXICITY IN RAT BRAIN (SHORT COMMUNICATION)

Author(s)

KHALATBARY ALI REZA | GHAFFARI ELMIRA | MOHAMMADNEGAD BEHROOZ | Issue Writer Certificate

Keywords

DELTAMETHRIN

OLEUROPEIN

APOPTOSIS

Abstract

Background: DELTAMETHRIN (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to APOPTOSIS. There is accumulating evidence that OLEUROPEIN (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Methods: Rats were randomly divided into four groups each containing five rats: DM-treated group (12.5 mg/kg, a single dose), OE-treated group (20 mg/kg per day), DM + OE-treated group, and vehicle group. Sections of the brain were obtained 24 hours after DM injection and studied for histopathological and immunohistochemistry assessment. Results: The histopathological assessments showed lesser characteristics of neural degeneration in DM + OE group compared with DM group. Greater Bcl-2 and attenuated Bax expression could be detected in the DM + OE treated mice compared with DM group. Conclusion: The results suggested that DM-induced neurotoxicity can be subsided by OE.

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APA: Copy

KHALATBARY, ALI REZA, GHAFFARI, ELMIRA, & MOHAMMADNEGAD, BEHROOZ. (2015). PROTECTIVE ROLE OF OLEUROPEIN AGAINST ACUTE DELTAMETHRIN- INDUCED NEUROTOXICITY IN RAT BRAIN (SHORT COMMUNICATION). IRANIAN BIOMEDICAL JOURNAL, 19(4), 247-253. SID. https://sid.ir/paper/277442/en

Vancouver: Copy

KHALATBARY ALI REZA, GHAFFARI ELMIRA, MOHAMMADNEGAD BEHROOZ. PROTECTIVE ROLE OF OLEUROPEIN AGAINST ACUTE DELTAMETHRIN- INDUCED NEUROTOXICITY IN RAT BRAIN (SHORT COMMUNICATION). IRANIAN BIOMEDICAL JOURNAL[Internet]. 2015;19(4):247-253. Available from: https://sid.ir/paper/277442/en

IEEE: Copy

ALI REZA KHALATBARY, ELMIRA GHAFFARI, and BEHROOZ MOHAMMADNEGAD, “PROTECTIVE ROLE OF OLEUROPEIN AGAINST ACUTE DELTAMETHRIN- INDUCED NEUROTOXICITY IN RAT BRAIN (SHORT COMMUNICATION),” IRANIAN BIOMEDICAL JOURNAL, vol. 19, no. 4, pp. 247–253, 2015, [Online]. Available: https://sid.ir/paper/277442/en

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